02228nas a2200205   4500008004100000245015300041210006900194260001800263300001400281490000700295520151800302653001701820653005301837100001601890700001801906700001801924700002101942700001901963856004001982       2021                        eng d00aVerbascum Thapsus (Mullein) Versatile Polarity Extracts: GC-MS Analysis, Phytochemical Profiling, Anti-bacterial Potential and Anti-oxidant Activity0 aVerbascum Thapsus Mullein Versatile Polarity Extracts GCMS Analy  cNovember 2021  a1488-14970 v133 a<p class="rtejustify">Verbascum thapsus is naturally grown in the Himalayas and widely used in herbal teas and traditional herbal medicine for its anticarcinogenic and anti-inflammatory properties. The present study was designed to majority of leaf extracts from Verbascum thapsus. All extracts were analysed for phytochemical properties, antioxidant capacity and antimicrobial potential against both Gram-positive and Gram-negative bacteria. Biochemical investigations and GC-MS analysis was used for identifying phytochemicals. DPPH assay, Kirby’s Disc Diffusion method (KDM), 96 well test, and Resazurin test were performed for antioxidant and antimicrobial investigation. Results indicate that verbascum thapsus grown in Pakistan is rich in alkaloids and phenols. Noteworthy antibacterial activity was observed against S. sonnei, L. lactis, B. subtilis, C. freundii, K. oxytoca, L. monocytogenes, and S. enterica. GCMS analyses of V. thapsus extracts revealed the presence of medically important bio compounds including Hexadecanoic acid, methyl es and Stigmasterol (antibacterial activity), 2(5H)-Furanone (appetite suppressant), 3-Hydroxy-.beta.-damascone (anti-inflammatory properties), Squalene (antiaging, anti-inflammatory, anti-acne, eczema), Vitamin E and 2-Methoxy-4-vinylphenol (antioxidants). Antioxidant radical scavenging activity was determined from acetone extract of V. thapsus. This study concludes remarkable antibacterial and antioxidant potential in Verbascum Thapsus leaf extracts</p>
10aMicrobiology10aVerbascum Thapsus; GC/GC-MS; plant biotechnology1 aNadeem, Ali1 aAhmed, Bashir1 aShahzad, Hira1 aCraker, Lyle, E.1 aMuntean, Tudor  uhttps://www.phcogj.com/article/1688