01822nas a2200193 4500008004100000245012200041210006900163260001800232300001400250490000700264520118700271653001201458653001301470653000901483653002801492100003301520700003501553856004001588 2021 eng d00aEffect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice0 aEffect of Muntingia calabura L Leaf Extract on Blood Glucose Lev cNovember 2021 a1450-14550 v133 a

Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. Methods: The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. M. calabura leaf extract with 100 and 300 mg/kg and 600 μg/kg of glibenclamide was given orally for 14 days. Results: The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the M. calabura leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the M. calabura leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group. Conclusion: M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice.

10aAlloxan10aDiabetes10aMice10aMuntingia calabura leaf1 aSolikhah, Tridiganita, Intan1 aSolikhah, Gahastanira, Permata uhttps://www.phcogj.com/article/1682