02584nas a2200289 4500008004100000245010600041210006900147260001800216300001400234490000700248520173200255653001701987653001402004653000902018653002302027653001602050653001302066100001902079700001802098700002202116700001802138700002302156700002502179700002602204700002402230856004002254 2021 eng d00aProtective effect of Salvia officinalis against cypermethrininduced reprotoxicity in male Wistar rats0 aProtective effect of Salvia officinalis against cypermethrinindu cNovember 2021 a1413-14210 v133 a

Background: Medicinal plants are a reservoir of biologically active compounds with therapeutic properties that, over time, have been used for the treatment of various diseases. This study aims to evaluate the protective effect of the aqueous extract of the leaves of Salvia officinalis against cypermethrin-induced toxicity. Methods: 30 male rats weighing approximately 240 g were divided into equal six groups; the control group received tap water, the positive control received the aqueous extract of sage leaves (SLE) at a dose of (0.5g/kg bw), the groups treated with cypermethrin (Cyp1) at 8.33 mg/kg bw and (Cyp2) at 25 mg/kg bw, and the groups treated by cypermethrin combined with aqueous extract of sage SLE+Cyp1 (0.5g/kg bw+8.33 mg/kg bw) and SLE+Cyp2 (0.5g/kg bw+25 mg/kg bw) for four days/week. After 4 weeks of oral administration, epididymal seminal fluid was analyzed via the CASA system, in addition to the histological study testis and epididymis. Results: The obtained results showed a decrease in the absolute weight of the reproductive organs, with a significant decrease in sperm concentration, motility and speed in the cypermethrin-treated group compared to the control. Histological study of the testes and epididymis indicates an alteration in the stages of spermatogenesis in groups Cyp1 and Cyp2 compared to the control. However, the above-mentioned parameters were maintained almost normal in the groups that received the aqueous extract of sage with both doses of cypermethrin. Conclusion: it can be demonstrated that SLE has been shown to protect rats from cypermethrin-induced reprotoxicity.

10aCypermethrin10aHistology10aRats10aSalvia officinalis10aSpermatozoa10aToxicity1 aCHOUABIA, Amel1 aDJEMLI, Samir1 aABDENNOUR, Cherif1 aMALLEM, Leila1 aKAHALERRAS, Labiba1 aARKOUB, Fatma, Zohra1 aBOUABDALLAH, Narimene1 aTAHRAOUI, Abdelkrim uhttps://www.phcogj.com/article/1677