01956nas a2200241 4500008004100000245020200041210006900243260001900312300001400331490000700345520107800352653002901430653001701459653001601476653003501492653002801527653003501555100001901590700001601609700002101625700002801646856004001674 2021 eng d00aApplication of Ultrasound-Assisted Extraction on the Stem Bark of Rhinachantus Nasutus (L.) Kurz, Total Phenolic, and Its Potential as Antioxidant and Inhibitor of Alpha-Glucosidase Enzyme Activity0 aApplication of UltrasoundAssisted Extraction on the Stem Bark of cSeptember 2021 a1297-13030 v133 a

Aims: This study aims to obtain a stem bark extract of Rhinachantus nasutus (L.) Kurz through the application of ultrasound-assisted extraction (UAE) and reveal: the total phenolic content in the extract; The extract's potential as an antioxidant with copper-reducing strength parameters, and its potential as an antidiabetic by inhibiting alpha-glucosidase activity. Results: The crude ethanol extract of R. nasutus stem bark obtained from the UAE process was 7.4896 g with a yield of 4.99%. The high total phenolic content, namely 677.3343±0.0007 mg GAE / g sample, the antioxidant activity test using the CUPRAC method gave an IC50 value of 18.43±0.20 mg / L. In addition, the ethanol extract of stem bark has a high ability to inhibit the activity of the alpha-glucosidase enzyme with an IC50 value of 10.95±0.28 mg / L. Conclusion: The ethanol extract of the stem bark of R. nasutus from UAE has the potential as a source of antioxidants and antidiabetic.

10aAlpha-glucosidase enzyme10aAntidiabetic10aAntioxidant10aRhinachantus nasutus (L.) Kurz10aTotal phenolics content10aUltrasound-assisted extraction1 aIrawan, Candra1 aElya, Berna1 aHanafi, Muhammad1 aSaputri, Fadlina, Chany uhttps://www.phcogj.com/article/1661