01937nas a2200217 4500008004100000245010500041210006900146260001900215300001400234490000700248520125900255653001901514653003801533653001601571653001301587100002901600700002001629700002501649700000501674856004001679 2021 eng d00aMyocardium Neutrophil Infiltration in Rat Model with Acute Myocardial Infarction Treated by Ramipril0 aMyocardium Neutrophil Infiltration in Rat Model with Acute Myoca cSeptember 2021 a1116-11210 v133 a

Introduction: Acute myocardial infarction (AMI) is a cardiovascular disease that attacks myocardial cells due to long-standing ischemia. In AMI there is neutrophil infiltration associated with the prognosis of the disease. One of the initial therapies for AMI is ACE inhibitors. Objective: To determine myocardial neutrophil infiltration In rat model with acute myocardial infarction which is given ramipril as an Ace inhibitor. Method: This research is an experimental study using the Post Test Only Control Group study design. This study used 24 experimental rats which were divided into 3 treatment groups. Data were analyzed using the One Way ANOVA test and the Least Significant Differences test. Results: The results obtained were the mean number of neutrophils in the K(-) group was 1.83, the K(+) group was 22.67, and the successive treatment group was 4,17. Significant differences were obtained between the K(+) group and the treatment group where the p value was 0.001 (p <0.05). Conclusion: There is an effect of 4 mg/kg BW ACE Inhibitor ramipril and on the number of myocardial neutrophils of rats with AMI.

10aACE inhibitors10aAcute Myocardial Infarction (AMI)10aNeutrophils10aRamipril1 aOktomalioputri, Biomechy1 aSavitri, Meutia1 aDillasamola, Dwisari1 a uhttps://www.phcogj.com/article/1640