02485nas a2200241 4500008004100000245009200041210006900133260001900202300001400221490000700235520179800242653002102040653000802061653000802069653001102077653001402088100002902102700001902131700003002150700001802180700000502198856004002203 2021 eng d00aMIC and MKC Analysis of Herbal Medicine in Indonesia Against Mycobacterium tuberculosis0 aMIC and MKC Analysis of Herbal Medicine in Indonesia Against Myc cSeptember 2021 a1058-10640 v133 a

Data shows that the success of the Directly Observed Treatment Shortcourse program(DOTS) in South Sulawesi Province was 74.8%. Causes of failure include standard drug side effects, length of treatment period and Mycobacterium tuberculosis (M.tb) bacterial resistance. The development of new drugs today in addition to synthetic chemical drugs are also natural materials that have the potential as antituberculosis with various mechanisms. The aim of the research is to prove the potential of plants used by the community as tuberculosis drugs empirically based on phytochemical screening extracts, M.tb sensitivity to extracts and determine the MIC (Minimum Inhibitory Concentration) and MKC (Minimum Killing Concentration) values of M.tb. Selection of plant test materials based on survey results and Riskesdas data in 2015. Testing the potential of plant extracts based on the sensitivity of M.tb to the test material in vitro with an incubation period of 7 weeks. Showed 25 plants that have been used empirically as tuberculosis drugs proved to be potential antibacterial M.tb. Phytochemical screening produces flavonoids and tannins in all extracts. Some extracts contain alkaloids, saponins and steroids. Potential tests show that the extract concentration that is effectively used as a tuberculosis drug is: Meniran leaves and miana 100 ppm. Banana peel and basil leaves 125 ppm. 150 ppm bangle rhizome. Turmeric rhizome 175 ppm. Roselle flowers, soursop leaves and lime 200 ppm. Sandalwood, bitter melon leaves and binahong 225 ppm, Curcuma rhizome, kencur, turmeric and onion tubers, gotu kola leaves, sea lava and papaya 275 ppm. Ginger rhizome, brotowali stem, noni leaf, cloves and mangosteen peel > 275 ppm. 90% garlic bulb extract.

10aAntituberculosis10aMIC10aMKC10aPlants10aPotential1 aPakadang, Sesilia, Rante1 aHilaria, Maria1 aDewi, Sisilia, Teresia Ro1 aSinala, Santi1 a uhttps://www.phcogj.com/article/1633