02762nas a2200313 4500008004100000245013700041210006900178260001400247300001200261490000700273520172600280653001702006653000902023653001002032653001602042653000802058100002902066700003402095700002902129700003302158700003102191700003302222700003102255700003402286700002902320700003302349700002602382856004002408 2021 eng d00aAntioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats0 aAntioxidant and Hepatoprotective Activity of Ethanol Extract of  cJuly 2021 a874-8820 v133 a

Background: Annona cherimola Mill. (A. cherimola) is mainly characterized by its antioxidant and cytoprotective properties due to their content of phenolic compounds. Objective: To evaluate antioxidant and hepatoprotective activity of ethanol extract of leaves from A. cherimola against induced toxicity by paracetamol in rats. Methods: Amount of total phenolics compounds of ethanol extract of A. cherimola Mill. was determined by the Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Three doses of the ethanol extract of leaves of A. cherimola (250, 500 and 750 mg/Kg/day) were administered to rats and it was evaluated biochemical blood parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured, liver tissue was removed for histopathological analysis. Results: Ethanol extract of leaves from A. cherimola had 41.26 mg GAE/g extract and antioxidant DPPH Scavenging Activity had 85.51%. A. cherimola reduced blood levels of ALT, AST and ALP, compared to control group Paracetamol, ethanol extract, being more effective at doses of 750 mg/Kg/day. Histopathological evaluation suggested that A. cherimola decreased hepatic necrosis and degenerative process induced by paracetamol. Conclusions: Hepatoprotective activity of ethanol extract of leaves of A. cherimola was demonstrated, being hepatoprotective activity dose dependent and the mechanism may involve antioxidant activity and total polyphenols found in extract of this plant.

10aAntioxidants10aDPPH10aLiver10aParacetamol10aRat1 aSilva-Correa, Carmen, R.1 aLa Torre, Víctor, E. Villarr1 aCruzado-Razco, José, L.1 aGuarniz, William, Antonio Sa1 aGonzález-Blas, María, V.1 aGonzález-Siccha, Anabel, D.1 aCalderón-Peña, Abhel, A.1 aVillalaz, Cinthya, L. Aspajo-1 aGuerrero-Espino, Luz, M.1 aDel Rosario-Chávarri, Jorge1 aHilario-Vargas, Julio uhttps://www.phcogj.com/article/1607