02109nas a2200241 4500008004100000245010700041210006900148260001800217300001000235490000600245520136600251653002401617653002501641653001401666653002501680100002101705700002801726700001801754700001901772700001901791700001701810856004001827 2014 eng d00aPhytochemical Investigation, Antioxidant and Antifungal Activities of Rhizomes of Euphorbia Fusiformis0 aPhytochemical Investigation Antioxidant and Antifungal Activitie c26th May 2014 a78-820 v63 a

Objective: Isolation of compounds from Euphorbia fusiformis rhizomes and evaluation of extracts and each isolates for its antioxidant and antifungal activities. Results: Five compounds were isolated including Euphol 1, β-Sitosterol 2, Caudicifolin 3, Scoparone 4 and Scopoletin 5. The occurrence of the compounds 2, 4 and 5 in the herb reported here for the first time. The ethyl acetate extract showed significant antioxidant activity (IC50 = 2.781 mg/ml) and its yielded compound 3 showed moderate antioxidant activity (IC50 = 3.25 mg/ml) using DPPH method. The ethyl acetate extract showed better antifungal activity against Aspergillus niger and Candida albicans. Conclusion: Compounds 2, 4, 5 were isolated first time from this plant. The ethyl acetate extract showed significant antioxidant and antifungal activity against A. nigar and C. Albicans. Thus, this study concludes by demonstrating the isolation, characterization, antioxidant and antifungal properties of E. fusiformis, which may have further therapeutic value.

Key Words:Euphorbia fusiformis, coumarins, antioxidant activity, antifungal activity.

10aAntifungal activity10aantioxidant activity10aCoumarins10aEuphorbia fusiformis1 aDevendar, Ponnam1 aSrinivas, K.V.N., Satya1 aKumar, Kotesh1 aKumar, Sandeep1 aBhagel, Savita1 aSastry, K.P. uhttps://www.phcogj.com/article/1527