01808nas a2200217 4500008004100000245017500041210006900216260001800285300001000303490000600313520105100319653002101370653001401391653002201405653002501427653003001452100001901482700003001501700001901531856004001550 2014 eng d00aPhysico Chemical Characterization and Anti Inflammatory Activity of Stem Extracts Of Berberis aristata DC and Cosinium fenestratum Linn in Carrageenan Induced Wistar Rats0 aPhysico Chemical Characterization and Anti Inflammatory Activity c26th May 2014 a72-770 v63 a

An initial study on the physico-chemical properties of Berberis aristata and Cosinium fenestratum, both used as Daruharidra by the Ayurvedic drug industry, recorded all the tested parameters within the limits of Ayurvedic Pharmacopeia of India. Also, analysis of secondary metabolite of the plants was carried out focusing on the presence and quantification of berberine in the samples. Further, the potential difference in the anti-inflammatory activity of the aqueous and methanolic stem extracts of the two species was compared using carrageenan induced Wistar rats model. At a dose of 25 mg/kg, the aqueous and methanolic crude extracts of both the plant species showed significant inhibition of rat paw edema at various time intervals viz.,0, 30, 60, 120 and 240 minutes as against the control standard drug indomethacin (p<0.01, p<0.001).

Key words: antiinflammation, Berberine, Berberis aristata, Cosinium fenestratum, Physico-chemical analysis.

10aAntiinflammation10aBerberine10aBerberis aristata10aCosinium fenestratum10aPhysico-chemical analysis1 a.Tamilselvi, S1 aVenkatasubramanian, Padma1 aVasanthi, N.S. uhttps://www.phcogj.com/article/1526