02310nas a2200217 4500008004100000245012900041210006900170260001800239300001000257490000600267520160700273653002101880653002201901653002001923653002101943653002001964100002001984700002402004700002402028856004002052 2014 eng d00aImmunomodulatory Effect of Water Soluble Polysaccharides Isolated from Metroxylon sagu in Animal Models of Immunosuppression0 aImmunomodulatory Effect of Water Soluble Polysaccharides Isolate c2nd July 2014 a55-620 v63 a

Aim: This study was aimed to investigate the immunomodulatory activity of water soluble polysaccharides isolated from Metroxylon sagu (PSMS) by dilute acid extraction, ethanol precipitation in rats by using three different in-vivo experimental models of immunosuppression. Methodology: Three models of immunosuppression include metronidazole (MTZ) induced immunosuppression, pyrogallol induced immunosuppression and Ethanol-induced immunosuppression. Immunological indices like humoral antibody titer values, cellular immune response, percent change in phagocytosis, serum immunoglobulins were estimated. Histopathology of spleen was done in all control and treated groups. The doses of 500 and 250 mg/kg of PSMS were administered orally to evaluate the immunomodulatory activity. Results: Though PSMS was demonstrated to have immunostimulatory activity in almost all three models of immunosuppression, PSMS was found to be more effi cacious against ethanol-induced immunosuppression when compared with pyrogallol induced immunosuppression and MTZ induced immunosuppression. However, dose-dependent improvement in immunological indices was evident in all three models. Conclusion: In summary, water soluble polysaccharides isolated from M. sagu stimulate the immunity in the animal models of immunosuppression.

Key words: Immunomodulation, immunosuppression, Metroxylon sagu, oxidative stress, polysaccharides.

10aImmunomodulation10aimmunosuppression10aMetroxylon sagu10aOxidative stress10aPolysaccharides1 aPulla, Sireesha1 aSannithi, Nagarjuna1 aChalla, Siva, Reddy uhttps://www.phcogj.com/article/1512