02764nas a2200205 4500008004100000245012100041210006900162260001900231300001000250490000600260520206700266653004802333653002702381100002502408700002102433700002102454700002302475700002002498856004002518 2014 eng d00aChemical constituents with free-radical-scavenging activity from the leaves of Lantana montevidensis (Spreng.) Briq.0 aChemical constituents with freeradicalscavenging activity from t c3rd Sept, 2014 a27-310 v63 a

Background: Seventy percent aqueous methanolic extract of the leaves of Lantana montevidensis exhibited antibacterial, anti-inflammatory, anti-pyretic, antioxidant and analgesic activities. Previous phytochemical study of the leaves led to the isolation of various flavones, pentacyclic triterpenoids, β-sitosterol and benzoic acid. Materials and Methods: The 70% aqueous methanolic extract of L. montevidensis (Spreng.) Briq. leaves was partitioned between water and n-hexane, CHCl3, EtOAc, and n-BuOH, successively. By using a series of different chromatographic techniques, the CHCl3 and EtOAc extracts afforded nine compounds. The isolated compounds were identified by spectroscopic techniques and by comparison with literature values and/or authentic samples. The free radical scavenging activity of some of the isolated compounds was evaluated. Results: Hispidulin-7-O-glucurnoide methyl ester (1), hispidulin-7-O-glucoside (2), cinaroside (3), nepetin-7-O-glucoside (4) pectolinarigenin (5), apigenin (6), luteolin (7) in addition to salicylic acid (8) and β-sitosterol-3-O-glucoside (9) have been isolated. Compounds 1-4 are first report from the genus Lantana while compounds 5, 8 and 9 are first report from this plant. The structures of these compounds were elucidated on the basis of spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data and/or authentic samples. Additionally, some of the isolated flavonoids exhibited free radical scavenging activity. Conclusion:Lantana montevidensis (Spreng.) Briq. cultivated in Egypt is rich in biologically active ingredients.

Key words:  Apigenin, cinaroside, free radical scavenging activity, hispidulin-7-O-glucurnoide methyl ester, hispidulin-7-O-glucoside, Lantana montevidensis, luteolin, nepetin-7-O-glucoside, pectolinarigenin.

10aFlavonoids free radical scavenging activity10aLantana montevidensis.1 aMakboul, Makboul, A.1 aAttia, Ahmed, A.1 aFarag, Salwa, F.1 aMohamed, Nesma, M.1 aRoss, Samir, A. uhttps://www.phcogj.com/article/1501