02504nas a2200217 4500008004100000245009100041210006900132260001900201300001200220490000600232520187900238653002502117653001602142653001302158653001202171653001202183653002802195100000502223700001802228856004002246 2014 eng d00aPharmacological Evaluation of Cucumber for Cognition Enhancing Effect on Brain of Mice0 aPharmacological Evaluation of Cucumber for Cognition Enhancing E c8th April 2014 a100-1070 v63 a

Introduction: Cucumber is fruit of Cucumis sativus var. sativus L. which has been used traditionally in gastrointestinal problems, skin problems and as coolant in salad for body and brain. Cucumber is a great folk medicine used to reduce heat and inflammation. Cognitive effects of cucumber are assessed in this study. Methods: Fresh fruits of Cucumis sativus L. were ground and a paste was prepared which consisted of different concentrations of cucumber (10, 20, 30 % w/w). The three doses were given ad libitum to mice for 15 successive days. Animal models utilized were sodium nitrite induced hypoxia and object recognition task. Biochemical analysis employed estimation of acetylcholinesterase activity in brain, serum glucose levels, cholesterol levels, brain lipid peroxidation (MDA) levels and reduced glutathione levels in brain of mice. Results: 6g/kg and 9g/kg doses of cucumber significantly (P< 0.05, P< 0.01) increased frequency of entry, number of entry and duration of entry in small compartment in sodium nitrite induced hypoxia model and depicted significantly (P< 0.05, P< 0.001) enhanced exploratory activity in object recognition task model. Further, biochemical analysis indicated good potential of cucumber in cognition enhancement. 9 g/kg dose (P< 0.001) reduced brain AchE activity along with blood glucose and serum cholesterol levels. 6 g/kg dose (P< 0.01) replenished brain GSH levels and reduced lipid peroxides. Conclusion: Cucumber increased cognition in rodents.

Key words: Hypoxia, object recognition task, acetylcholinesterase, glucose, cholesterol, dementia.

10aAcetylcholinesterase10aCholesterol10aDementia10aGlucose10aHypoxia10aobject recognition task1 a1 aParle, Milind uhttps://www.phcogj.com/article/1494