01816nas a2200205 4500008004100000245005300041210005300094260001900147300001000166490000600176520119100182653003101373653002801404653003701432653001601469100002901485700002501514700003101539856004001570 2014 eng d00aChemical Constituents of Dendrobium williamsonii0 aChemical Constituents of Dendrobium williamsonii c8th April 2014 a36-410 v63 a

Objective: Isolation of compounds from Dendrobium williamsonii and evaluation of each isolates for its free radical scavenging, antiherpetic and cytotoxic activities. Results: Six phenolic compounds were isolated including tetratriacontanyltrans- p-coumarate (1), trans-docosanoylferulate (2), 3,3′-dihydroxy-4,5-dimethoxybibenzyl (3), moscatilin (4), apigenin (5) and vanillic acid (6). Among these isolates, compounds 3, 4 and 5 exhibited recognizable DPPH free radical scavenging potential.Only 3 exhibited weak activity against Herpes simplex virus, whereas 3 and 4 showed cytotoxicity against KB and MCF-7 cancer cells. Conclusion: This study is the first report on the chemical and biological properties of D. williamsonii.Compounds 3, 4 and 5 are responsible for free radical scavenging activity of this plant. Compound 4 showed the strongest cytotoxic effect on KB cancer cells.

Key words:Dendrobium williamsonii, Orchidaceae, Anti-herpetic Cytotoxicity, Free radical scavenging activity.

10aAnti-herpetic Cytotoxicity10aDendrobium williamsonii10aFree Radical Scavenging Activity10aOrchidaceae1 aRungwichaniwat, Pathrapa1 aSritularak, Boonchoo1 aLikhitwitayawuid, Kittisak uhttps://www.phcogj.com/article/1487