02351nas a2200241 4500008004100000245013800041210006900179260001800248300001000266490000600276520159100282653001701873653002101890653001501911653001401926653001701940100002501957700001601982700001701998700002402015700003002039856004002069 2015 eng d00aAnti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis0 aAntiNociceptive Synergism of Pregabalin and Xylopic acid Coadmin c7th July 2015 a55-570 v73 a

Background: Paclitaxel-induced neuropathy still remains a clinical problem for patients undergoing chemotherapy. Objective: The objective of the study was to determine the interaction between xylopic acid and pregabalinco-administration as well as their toxicity in paclitaxel-induced neuropathy. Materials and Methods: Neuropathic pain was induced in rats with 2 mg/kg of paclitaxel on alternative days for four days (days 0, 2, 4 and 6). Equi effective doses of xylopic acid and pregabalin that produced 50% anti-nociception (ED50) were determined from their log-dose response curves in the cold allodynia and thermal pain tests. Xylopic acid and pregabalin were again administered to rats in a fixed ratio combination (1:1) of their ED50’sin order to determine the experimental ED50 (Zexp) of the co-administered compounds. Isobolograms were constructed to compare the Zexp to a theoretical ED50 (Zadd). Blood samples from the various treatment groups of rats were collected for toxicological assessment of the co-administered compounds. Results: The Zexplay below the Zadd on the isobologram of the cold allodnia test. The co-administration exhibited additivity in the thermal pain test. The co-administration did not produce significant (p>0.05) toxicity in rats. The co-administration may be beneficial in paclitaxel-induced neuropathy.

Key words: Isobolograms, Neuropathic pain, Paclitaxel, xylopic acid, Toxicity.

10aIsobolograms10aNeuropathic pain10aPaclitaxel10aToxicity.10axylopic acid1 aOfori, Ameyaw, Elvis1 aEric, Woode1 aSamuel, Kyei1 aRobert, Biny, Peter1 aNyarko, Boampong, Johnson uhttps://www.phcogj.com/article/1447