01864nas a2200205 4500008004100000245015100041210006900192260001500261300001200276490000700288520119600295653001201491653001801503653002601521653001801547653002001565100000501585700002801590856004001618 2021 eng d00aEvaluation of Co-administration of Roselle Water Extract (Hibiscus sabdariffa L.) and Aspirin for Antiplatelet Therapy in Male Sprague-Dawley Rats0 aEvaluation of Coadministration of Roselle Water Extract Hibiscus cMarch 2021 a563-5690 v133 a

Background: Various herbal side effects caused by interactions between herbs and drugs have been reported and reviewed. For instance, roselle water extract and aspirin have similar functions in maintaining cardiovascular function. Objective: This study aimed to investigate the effect of roselle water extract on aspirin pharmacodynamics observed through the parameters of bleeding time, survival rate and the number of microthrombus that induced thromboembolism in rats. Materials and Methods: Male Sprague-Dawley rats were divided into two different experimental group for bleeding time and survival rate assay. Roselle water extract was given in three various doses (12.5 mg, 25 mg, 50 mg/200 g BW) for seven days followed by aspirin on the last treatment. Results: Results showed that the co-administration of roselle water extract and aspirin did not cause significant changes in the increase in bleeding time, the number of animals that survived and the number of microthrombus. Conclusion: Therefore, roselle water extract does not affect the pharmacodynamics of aspirin.

10aAspirin10aBleeding time10aRoselle water extract10aSurvival rate10aThromboembolism1 a1 aSaputri, Fadlina, Chany uhttps://www.phcogj.com/article/1394