02212nas a2200301 4500008004100000245007300041210006900114260001700183300001200200490000600212520137700218653001501595653001001610653001701620653001301637653001501650100001801665700002101683700001701704700001901721700002601740700001801766700002001784700001601804700003201820700001901852856003901871 2016 eng d00aUpdates on Traditional Medicinal Plants for Hepatocellular Carcinoma0 aUpdates on Traditional Medicinal Plants for Hepatocellular Carci cJanuary 2016 a203-2140 v83 a

Aim: Hepatocellular carcinoma (HCC) is a major worldwide problem primarily caused by hepatitis B and C virus infection. End stage liver cancer treatment options are limited thus requiring expensive liver transplantation which is not available in many countries. Methods: Several herbal compounds and herbal composite formulas have been studied through in-vitro and in vivo as an anti-HCC agent, enhancing our knowledge about their biological functions and targets. In this article, arecent update on the herbal medicine has been provided with reference to liver cancer. Results: For the sake of clarity, the effective herbal compounds, clinical studies of herbal composite formula, cell culture, and animal model studies safety are discussed. The effects of many herbal active compounds of Annona atemoya, Andrographis paniculata, Boerhaviadiffusa, Piper longum, Podophyllum hexandrum, Phyllanthus amarus, and Terminalia chebula, and herbal composite formula on autophagy, apoptosis, antioxidant, and inflammation characteristicshave been provided. Conclusion: This will enhance our understanding on the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

10aAnticancer10aHerbs10aLiver cancer10aMedicine10aTreatment.1 aMathew, Shilu1 aFaheem, Muhammad1 aSuhail, Mohd1 aFatima, Kaneez1 aArchunan, Govindaraju1 aBegum, Nargis1 aIlyas, Muhammad1 aAzhar, Esam1 aDamanhouri, Ghazi, Abdullah1 aQadri, Ishtiaq uhttps://www.phcogj.com/article/137