01891nas a2200217 4500008004100000245013200041210006900173260001700242300001200259490000700271520124900278653001501527653001401542653002801556653001001584653001001594100000501604700001901609700000501628856004001633 2021 eng d00aCytotoxicity Effect of the Pericarp Extracts of Garcinia forbesii King on MCF-7 Breast Cancer and HepG2 Liver Cancer Cell Lines0 aCytotoxicity Effect of the Pericarp Extracts of Garcinia forbesi cJanuary 2021 a226-2290 v133 a

Background: The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. Materials and Methods: The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer.

10aAnticancer10aCytotoxic10aGarcinia forbesii King.10aHepG210aMCF-71 a1 aPoerwono, Hadi1 a uhttps://www.phcogj.com/article/1355