01861nas a2200193   4500008004100000245009500041210006900136260001700205300001200222490000700234520128300241653000801524653000801532653001801540653001601558100003401574700001901608856004001627       2021                        eng d00aLiver Organ Impairment Due to the Consumption of Kratom Leaves (Mitragyna speciosa Korth.)0 aLiver Organ Impairment Due to the Consumption of Kratom Leaves M  cJanuary 2021  a179-1840 v133 a<p class="rtejustify">This study was aimed to evaluate the administration effects of kratom leaves extracts on the liver of mice (<em>Mus musculus</em>). The total of 25 mice was divided into five groups, respectively; (A) without treatment, (B) treatment with distilled water at 0.50 ml/20 g body weight, (C) treatment of kratom leaves extracts with a dosage of 0.15 mg/20 g body weight, (D) treatment of kratom leaves extracts with a dosage to 0.30 mg/20 g body weight and (E) treatment with a dosage of silymarin at 0.70 mg/20 g body weight. All those treatments were completed in seven consecutive days. On day 8, blood withdrawal and liver dissection were executed. The average levels of AST enzyme in the treatment groups respectively showed 22.81 U/L (A), 23.30 U/L (B), 34.86 U/L (C), 40.68 U/L (D), and 25.44 U/L (E), (p&lt;0.05). Whereas, the average levels of ALT exposed respectively at 17.96 U/L (A), 18.35 U/L (B), 29.13 U/L (C), 33.59 U/L (D), and 20.68 U/L (E), (p&lt;0.05). The average scoring for the treatment groups resulted in 0.33, 0.67, 1.33, 1.67, and 0.67, respectively, with p&lt;0.05. Hence, it was concluded that the higher doses of the extracts of kratom leaves administered during the treatment, the more severe damage the liver organ became.</p>
10aALT10aAST10aKratom leaves10aLiver organ1 aPanjaitan, Ruqiah, Ganda Putr1 aLiridah, Linda  uhttps://www.phcogj.com/article/1348