02121nas a2200265 4500008004100000245005200041210005100093260001800144300001400162490000700176520143300183653002201616653001401638653001201652653000801664653001401672653001401686100001901700700000501719700002801724700002501752700001601777700002201793856004001815 2020 eng d00aTopical Anti-Inflammatory Activity of Bromelain0 aTopical AntiInflammatory Activity of Bromelain cNovember 2020 a1586-15930 v123 a

Introduction: Bromelain is a proteolytic enzyme found in pineapple plants. Aim: This study conducted to determine the activity of bromelain enzyme as an anti-inflammatory using the Granuloma Pouch method. Methods: The experimental animals were divided into five groups, namely the positive control group, the bromelain concentration group of 0.1%; 0.5%; 1%, and the comparison group. Experimental animals induced carrageenan 2% subcutaneously. The dosage form is given topically for 2, 4, and 6 days. The observation was made by measuring the volume of edema, the total number, and the percentage of leukocyte cells on days 2, 4, and 6. Results: The observation results of a positive control group, bromelain concentration 0.1%, 0.5%, 1%, and the comparators, there was a significant decrease for the volume of exudate on days 2, 4, and 6 (p<0.05). The average total number of leukocytes also decreased significantly (p<0.05) in the positive control, the bromelain, and comparison group in day 2, 4, and 6. At the same time, the mean leucocyte percentage had no effect (p>0.05). Conclusion: From the results of the study, it was concluded that the bromelain enzyme at concentration 0.1%, 0.5%, and 1% have an anti-inflammatory effect by suppressing the volume of exudate, and the total number of leucocyte.

10aAnti-inflammatory10aBromelain10aExudate10aGel10aGranuloma10aLeukocyte1 aBadriyya, Elsa1 a1 aPratiwi, Amalia, Refina1 aDillasamola, Dwisari1 aAldi, Yufri1 aHusni, Elidahanum uhttps://www.phcogj.com/article/1293