02432nas a2200265 4500008004100000245010100041210006900142260001800211300001400229490000700243520162500250653001601875653002701891653001101918653002201929653001701951653002601968100002801994700002102022700001902043700001902062700002802081700001702109856004002126 2020 eng d00aLutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials0 aLutein A Comprehensive Review on its Chemical Biological Activit cNovember 2020 a1769-17780 v123 a

Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, antiinflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf‑2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.

10aAntioxidant10aInflammatory cytokines10aLutein10aMolecular targets10aPharmacology10aTranscription factors1 aFuad, Nurul, Iman Nurul1 aSekar, Mahendran1 aGan, Siew, Hua1 aLum, Pei, Teng1 aVaijanathappa, Jaishree1 aRavi, Subban uhttps://www.phcogj.com/article/1291