02465nas a2200265 4500008004100000245010700041210006900148260001800217300001400235490000700249520163500256653002901891653002201920653002001942653001501962653002301977100002002000700002102020700003402041700002202075700002002097700002202117700002002139856004002159 2020 eng d00aAcute Diuretic Activity of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. In Rats0 aAcute Diuretic Activity of the Aqueous Ethanol Root Extract of C cNovember 2020 a1552-15580 v123 a

Objective: This study was undertaken to justify and validate a very frequent traditional use of a very well-known and widely used plant by a large part of the Moroccan population. It’s about Corrigiola telephiifolia, and the activity in question is the diuretic activity. Methods: The aqueous ethanol root extract of CMethods:orrigiola telephiifolia (200 mg/kg, 400 mg/kg, and 700 mg/kg) was orally administered to rats. The urinary excretion rate and pH, and electrolyte excretion were measured in the urine of saline-loaded rats. Negative control group received only an equivalent volume of distilled water, while the positive control groups received the diuretic drugs hydrochlorothiazide at dose 10 mg/kg. Results: The results showed that hydrochlorothiazide induced significant diuresis and electrolytes excretion at 1, 6 and 24 h after the treatment. Both the higher doses of the extract produced a significant increase in urine volume than the control from the first hour until the end of observation. However, the lowest dose increased significantly only at 24 h after the treatment. With regard to the electrolyte excretion, the tested doses of CTRE which have shown a significant increase in Na+, K+ and Cl-excretion in comparison to normal control rats, are 400 and 700 mg/kg bw. Conclusion: These findings collectively indicate that the extracts of C. telephiifolia have a potential to induce diuresis markedly, and providing evidence, for its traditional use.

10aCorrigiola telephiifolia10aDiuretic activity10aDiuretic plants10aKaliuresis10aUrine electrolytes1 aZakariya, Imane1 aElhamdaoui, Omar1 aAndaloussi, Zineb, ibn lahmar1 aChergui, Abdelhak1 aAjal, El, Amine1 aTaghzouti, Khalid1 aNejjari, Rachid uhttps://www.phcogj.com/article/1286