02125nas a2200229 4500008004100000245012400041210006900165260001900234300001400253490000700267520133000274653002401604653002601628653002801654653002801682100003301710700002001743700003701763700002401800700003101824856004001855 2020 eng d00aChemopreventive Action of Garcinia Mangostana Linn. on Hepatic Carcinoma by Modulating Ornithine Decarboxylase Activity0 aChemopreventive Action of Garcinia Mangostana Linn on Hepatic Ca cSeptember 2020 a1383-13880 v123 a

Ornithine decarboxylase and alpha -L- fucosidase over-expression is associated with advanced hepatocellular carcinoma (HCC) development. The objective of this study was to elucidate the action of Garcinia Mangostana fruit extract (GME) on these overexpressed enzymes and apoptotic proteins in diethyl nitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats. The cancer was induced using DEN to the experimental rats and treated with GME (400 mg/ kg) to find its anticancer property. The lysosomal enzymes such as alpha-L-fucosidase, beta- D-glucosidase, ornithine decarboxylase activity (ODC), apoptotic and antiapoptotic proteins such as Bcl-2, Bax and Bcl-xl and H3 thymidine incorporation assay were done to prove GME’s chemo preventive property. DEN induction caused significant increase in the activities of ornithine decarboxylase; lysosomal enzymes and increased cell proliferation with decreased apoptosis were observed. In contrast, the groups with GME treated rat’s elicited significant (P < 0.001) reduction in ornithine decarboxylase, lysosomal enzymes and decreased cell proliferation with increased apoptosis. GME has effective chemo preventive property and can serve as an anticarcinogenic therapeutic drug against hepatocellular carcinoma.

10aDiethyl nitrosamine10aG. Mangostana extract10aHepatocellularcarcinoma10aOrnithine decarboxylase1 aVeeraraghavan, Vishnu, Priya1 aHussain, Sardar1 aBalakrishna, Janardhana, Papayya1 aRengasamy, Gayathri1 aMohan, Surapaneni, Krishna uhttps://www.phcogj.com/article/1257