02767nas a2200241 4500008004100000245012200041210006900163260001600232300001200248490000700260520199200267653001502259653001402274653002602288653002402314100003002338700002302368700002902391700002102420700001902441700002502460856004002485 2020 eng d00aAntifungal Activity of Neolignan Derivatives from Eusideroxylon zwageri Against Pathogenic Fungus Microsporum gypseum0 aAntifungal Activity of Neolignan Derivatives from Eusideroxylon  cAugust 2020 a993-9990 v123 a

Introduction: Bulian wood (Eusideroxylon zwageri) known as iron wood. It was known as wood source which fungi and insect resistant. These effects were interconnected with secondary metabolites contained within. Methods: Eusideroxylon zwageri wood powder was macerated with methanol and fractinated with n-Hexane, dichloromethane, ethyl acetate. Eusiderin I and Compound B were isolated from n-hexane fraction, while Compound C were isolated from dichloromethane fraction. Eusiderin I, compound A and Compound B were characterized using melting point, UV spectroscopy and compared with previous data. Antifungal activity test was conducted with Microsporum gypseum using paper disc method. Results: A research on antifungal activity of Neolignan derivatives from Eusideroxylon zwageri against pathogenic fungus Microsporum gypseum had been carried out. Eusiderin I, Compound B and Compound C were isolated from wood of Eusideroxylon zwageri. All three compounds are white crystals with melting point in such 99-100 oC, 110-112 oC, 98-99 oC, respectively and UV spectrum data is similar to reference. The antifungal activity test of Eusiderin I, Compound B and Compound C from Bulian wood (Eusideroxylon zwageri) to phatogen fungus of Microsporum gypseum showed that with five different concentrations (5, 25, 50, 100 and 200 ppm), Eusiderin I was a potent antifungal because it had a strong activity in inhibiting the Microsporum gypseum growth. The 5 days incubation test result showed that 50 ppm Eusiderin I could inhibit the Microsporum gypseum colony growth. The 100 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the Microsporum gypseum colony growth (= 93.9%). Conclusion: Based on this data, Eusiderin I can be indicated an antifungal candidate.

10aAntifungal10aEusiderin10aEusideroxylon zwageri10aMicrosporum gypseum1 aChaerunisaa, Anis, Yohana1 aMuhaimin, Muhaimin1 aSyamsurizal, Syamsurizal1 aHarizon, Harizon1 aMilanda, Tiana1 aWicaksono, Imam, Adi uhttps://www.phcogj.com/article/1226