02332nas a2200193 4500008004100000245011100041210006900152260001600221300001400237490000700251520171700258653001601975653002001991653002202011653001802033653002102051100002602072856004002098 2020 eng d00aThe Effect of Lentinus squarrosulus, (Mont.) Consumption on the Treatment of Gastritis in Male Wistar Rats0 aEffect of Lentinus squarrosulus Mont Consumption on the Treatmen cAugust 2020 a1093-10960 v123 a

Introduction: Gastritis or /and gastric ulcers are one of the most common symptoms which occur in a large amount of the population. It results in a very high amount of medication expense. This study investigated the prevention and treatment of gastritis or /and gastric ulcer actions using white log mushroom (Lentinus squarrosulus, (Mont.). Methods: White wistar rats were induced with 100 % absolute alcohol to be effective for gastritis and /or ulceration within rats. The gastric lesions of white wistar rats were investigated and calculated the lesions of stomach areas under microscopic method. The results were calculated and a comparative study among white wistar rats. Ulcer prevention and ulcer healing properties were administrated though a dose of 250 mg/kg of L. squarrosulus extract and L. squarrosulus compared with 50 mg/kg of Ranetidine. Results: It was found that Lentinus squarrosulus, (Mont.) consisted of Beta-glucan was the active ingredient creating a healing effect. It showed a result of 100% healing effect in gastritis and/or ulcers in which it had similar healing effects between extracted solutions of white log mushroom (250 mg/kg body wt.) The healing activity also showed the equivalent effect compared to Ranetidine 150mg. Conclusions: Extracted solution of white log mushroom showed prevention and treatment efficacy in gastritis and/ or ulcer are equivalent to Ranetidine 150 mg. A similar dose of 250 mg/kg of L. squarrosulus extract and L. squarrosulus snack can prevent and heal ulcers and is more effective than Ranetidine.

10aBeta glucan10aL. squarrosulus10aRanetidine 150 mg10aUlcer healing10aUlcer prevention1 aSrichaikul, Buavaroon uhttps://www.phcogj.com/article/1212