03253nas a2200409 4500008004100000245011100041210006900152260001400221300001200235490000700247520216100254653001702415653001302432653001102445653000902456653002302465653002502488653001402513653001302527100001402540700001702554700001602571700001702587700001502604700001702619700002102636700002002657700001902677700001702696700001702713700000502730700001702735700001802752700001602770700001702786856004002803 2020 eng d00aModern Approaches to the Analysis of Kelp (Laminaria sp.) as Pharmacopoeial Herbal Drugs and Food Products0 aModern Approaches to the Analysis of Kelp Laminaria sp as Pharma cJune 2020 a929-9370 v123 a

Background: Currently, the chemical composition of Laminaria J.V. Lamour. species is well studied; they have found applications in the food, cosmeceutical and pharmaceutical industries. The main groups of biologically active compounds are polysaccharides (alginic acid, laminarin, mannitol, fucoidan, and others) and minerals (iodine compounds, magnesium, potassium, calcium, iron) that are determined according to pharmacopoeial and All-Union State Standards requirements. Materials and Methods: For data obtaining various types of search tools and engines such as Google, Google scholar, scientific literature (including Russian sources), normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition, All-Union State Standards, and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed were used. Results: In the course of this review study, a modern characteristic of the kelp thallus as a pharmaceutical, cosmeceutical, food substance of plant origin is presented. The data on the chemical composition, harvesting, and processing of raw materials are summarized. The standardization and safety issues of kelp thallus are considered taking into account modern pharmacopoeial and food international requirements. The approaches to the qualitative and quantitative analysis of biologically active compounds (polysaccharides, iodine) and the determination of safety indicators are studied. Conclusions: The regulatory documentation that is used in the quality control of kelp needs to be finalized and updated. For pharmacopoeial analysis, all possible physicochemical methods (gravimetric, titrimetric, spectrophotometric) should be presented in the newly approved monograph. In this case, modern procedures should be developed, including HPLC with various types of detection (determination of the carbohydrates profile and polysaccharides, including methods with acid and enzyme hydrolysis). This will ensure the required level of quality, the safety of kelp (Laminaria) raw materials.

10aalginic acid10aFucoidan10aIodine10aKelp10aLaminaria japonica10aLaminaria saccharina10aLaminarin10aMannitol1 aDO, Bokov1 aOG, Potanina1 aAV, Nikulin1 aVM, Shchukin1 aVA, Orlova1 aGB, Bagirova1 aSD, Kakhramanova1 aH, Al-, Khafaji1 aNP, Balobanova1 aAA, Evgrafov1 aIA, Samylina1 a1 aOA, Golubeva1 aES, Kuleshova1 aDV, Moiseev1 aVV, Bessonov uhttps://www.phcogj.com/article/1196