02466nas a2200217 4500008004100000245008900041210006900130260001400199300001200213490000700225520176800232653002602000653001402026653002402040100002902064700003202093700003402125700002602159700002302185856004002208 2020 eng d00aThe Development of Phyllanthus emblica Extract in Ethosomes for Hair Loss Prevention0 aDevelopment of Phyllanthus emblica Extract in Ethosomes for Hair cJune 2020 a905-9100 v123 a

Background: Hair loss is not a serious health problem but leads to decreased self- confidence, personality, and psychological problems. According to Thai traditional medical wisdom, Phyllanthus emblica has the property to prevent hair loss. Ethosomes are a drug delivery system, which can increase drug delivery to deep skin layers and enhance the effectiveness of the active ingredient. Objective: This research aims to develop ethosomes of Phyllanthus emblica extract with beneficial properties. Materials and Methods: Phyllanthus emblica was extracted by a maceration method with 95% ethanol as a solvent. The total phenolic content of the extracts was determined using the Folin-Ciocalteu method. The antioxidation activity was evaluated by DPPH assay. Ethosomes were formulated by a cold method and their properties were observed. Results: The results showed that the total phenolic content of Phyllanthus emblica extract was 406.37±2.39 mg GAE/g extract. The IC50 of antioxidant activity was 7.05±0.17 μg/ml. Ethosomes with 0.03% of Phyllanthus emblica extract, 2% of soya phosphatidylcholine, and 20% of ethanol had the highest percentage of entrapment efficiency (65.26%±1.80%). The ethosomes of Phyllanthus emblica extract was the spherical shape and white colloid. The particle size, polydispersity index, zeta potential, and pH of ethosomes were 0.43±0.00 μm, 0.44±0.03, -10.40±0.28 mV, and 4.06±0.03, respectively. Conclusion: The ethosomes of Phyllanthus emblica extract had good properties and area possible alternative product for hair loss prevention.

10aEntrapment efficiency10aEthosomes10aPhyllanthus emblica1 aLaovachirasuwan, Pornpun1 aFuangbangluang, Wutthichart1 aPhanichanaphan, Atchariyaporn1 aNasomroop, Issarapong1 aPhadungkit, Methin uhttps://www.phcogj.com/article/1192