02607nas a2200301 4500008004100000245015900041210006900200260001300269300001300282490000700295520159200302653002701894653001601921653001701937653001801954653002401972653001301996100003202009700002802041700002902069700002902098700001602127700002702143700003002170700003102200700003402231856004002265 2020 eng d00aAmeliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)0 aAmeliorative Effect of the Oral Administration of Chuquiraga spi cMay 2020 a562-568 0 v123 a

Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.

10aAnticarcinogenic agent10aAntioxidant10aBreast tumor10aPhytochemical10aPreventive medicine10aToxicity1 aArroyo-Acevedo, Jorge, Luis1 aHerrera-Calderon, Oscar1 aTinco-Jayo, Johnny, Aldo1 aRojas-Armas, Juan, Pedro1 aRauf, Abdur1 aHañari-Quispe, Renán1 aFigueroa-Salvador, Linder1 aFernández-Guzmán, Victor1 aYuli-Posadas, Ricardo, Ángel uhttps://www.phcogj.com/article/1146