02252nas a2200265 4500008004100000245007800041210006900119260001200188300001200200490000700212520148700219653002801706653001401734653001501748653002501763100001901788700001401807700003101821700001801852700001701870700002101887700001701908700002101925856004001946 2020 eng d00aAnti-arthritic Property of Sahacharadi Kashayam Against Freund's Complete0 aAntiarthritic Property of Sahacharadi Kashayam Against Freunds C cMay2020 a459-4640 v123 a

Introduction: The available modern molecular drugs for the therapy of Rheumatoid arthritis are beset with several side effects and alternative drugs are urgently needed. The present investigation was performed to evaluate the anti-arthritic activity of Sahacharadi Kashayam (SK), an Ayurvedic formulation, against Freund's complete adjuvant (CFA) - induced arthritis in rats. Methods: In this experimental trial, SK was administered at doses of 0.5, 1.0 and 1.5 ml/kg body weight orally to adjuvant (CFA) induced arthritic rats. The anti-arthritic activity was evaluated by using paw volume, haematological parameters and arthritic biomarkers. The efficacy of the Kashayam was compared with the standard Leflunomide (10 mg/kg) drug. Results: Significant reduction in paw volume and thickness by SK (0.5 ml dose) has been found and there was considerably improvement in haematological parameters and arthritic markers in CFA rats till 14 days. After 14th day SK treatment with doses (1.0 and 1.5ml), however, reoccurrence of inflammation and pathological changes were observed in rats. Conclusion: The study clearly indicated the anti-arthritic role of SK. Future studies, however, are warranted to provide a new approach in relation to the therapeutic dose and treatment period of SK which may eventually lead to the development of a new category of the anti-arthritic agent.

10aAnti-arthritic activity10aArthritis10aBiomarkers10aSahacharadi Kashayam1 aKumar, Praveen1 aPrabhu, K1 aRao, Mudiganti, Ram Krishn1 aJain, Mallika1 aKalaivani, K1 aDinakar, Shruthi1 aShil, Sampad1 aVijayalakshmi, N uhttps://www.phcogj.com/article/1133