01939nas a2200229 4500008004100000245016600041210006900207260001500276300001200291490000700303520123500310653001801545653001401563653001601577653002001593653000801613653000801621100001901629700001601648700000501664856004001669 2020 eng d00aAnti-Elastase, Antioxidant, Total Phenolic and Total Flavonoid Content of Wuru Ketek (Myrica javanica Reinw. ex Bl.) from Tangkuban Perahu, West Java - Indonesia0 aAntiElastase Antioxidant Total Phenolic and Total Flavonoid Cont cMarch 2020 a293-2970 v123 a

Introduction: The presence of elastase and ROS can cause skin aging, phenolic compounds and flavonoids can be used to inhibit elastase activity and as an antioxidant. Objective: This research aimed to evaluate the anti-elastase, antioxidant activities, TPC and TFC of extracts from Myrica javanica. Methods: In this study, the leaves, stems and fruit of Myrica javanica were macerated with 96% ethanol. The extracts obtained were analysed for anti-elastase and antioxidant activities. It was also evaluated for TPC and TFC. Result: IC50 anti-elastase on leaves extract (LE), stems extract (SE), and fruits extract (FE) respectively showed 64.71 ppm, 197.49 ppm, and no activity. The anti-elastase result of three extracts are lower if compared with Myricetine (9.54 ppm). SE showed highest DPPH and TPC value (IC50=16.36 μg/mL; 307.00 mgGAE/g dry weight) and LE showed highest FRAP and TFC value (421.68 Mol/gram; 15.80 mgQE/g dry weight). Conclusion: In summary, anti-elastase and antioxidant activity are influenced by differences in the content of compounds in the extract.

10aAnti-Elastase10aAntiaging10aAntioxidant10aMyrica javanica10aTFC10aTPC1 aArianti, Varda1 aElya, Berna1 a uhttps://www.phcogj.com/article/1118