02399nas a2200253 4500008004100000245015600041210006900197260001500266300001200281490000700293520154800300653003101848653001001879653001801889653001601907653001801923653001301941100003001954700003101984700003102015700003302046700002602079856004002105 2020 eng d00aFormulation and Evaluation of Safety and Antifungal Efficacy of Syzigium Aromaticum-Base Cream on Guinea Pigs Infected with Trichophyton Mentagrophytes0 aFormulation and Evaluation of Safety and Antifungal Efficacy of  cMarch 2020 a342-3500 v123 a

Background: The increasing incidence of dermatophytoses in the world and the side effects of the current therapies encouraged the search of alternative drugs. Hence the objective of this work was to determine antidermatophytes activity of Syzigium aromaticum formulate antidermatophytic cream. Materials and Methods: The extracts were prepared by maceration of plant materials into methanol. Three formulations of creams were made, and the best was chosen according to its physicochemical stability and appearance. The acute dermal toxicity and antidermatophytic efficacy of the cream was performed on guinea-pig. Results: The methanolic extract of S. aromaticum was incorporated in the final cream formulation. The formulation containing shea-butter 58.5%, acetylic alcohol 2.5%, stearic acid 1.5%, bee-wax 10%, borax 1.5%, polysorbate 60 2.5%, 2 drops of lactic acid and water was chosen because of its good appearance and stability. The cream with methanolic extract of S. aromaticum did not reveal any dermal toxic effect. The cream efficacy was dose-dependent. The treatment with cream at 5% methanolic extracts of S. aromaticum revealed the best potency after 14 days of treatment. Conclusion: These results show that the cream at 5% methanolic extract of S. aromaticum seed is promising in the treatment of dermatophytoses and could be used as an alternative in the development of a new therapy.

10aAntidermatophytes activity10aCream10aDermatophytes10aFormulation10aS. aromaticum10aToxicity1 aFokouo, Roger, Ducos Youm1 aFokou, Patrick, Valere Tso1 aMbouna, Cedric, Derick Jia1 aMenkem, Elisabeth, Zeuko’o1 aBoyom, Fabrice, Fekam uhttps://www.phcogj.com/article/1114