02142nas a2200241 4500008004100000245010300041210006900144260001900213300001200232490000700244520140800251653001901659653001901678653001901697653001401716653000801730100002801738700002401766700002901790700002001819700002101839856004001860 2020 eng d00aEfficacy of Allium sativum, Curcuma mangga and Acorus calamus Extract Combination on Rat Fertility0 aEfficacy of Allium sativum Curcuma mangga and Acorus calamus Ext cFebruary 2020 a197-2030 v123 a

Objective: to evaluate the efficacy of Allium sativum, Curcuma mangga, and Acorus calamus extract combination on female rat fertility. Methods: Thirty-six female rats were randomized divided into 9 groups (n=4): C- (no treatment); C+ (clomiphene citrate); composition 1 (A. sativum 36%: C. mangga 36%: A. calamus 28%) with 3 doses i.e T1, T2 & T3 of 50, 75 & 100 mg/kg BW; composition 2 (A. sativum 35%: C. mangga 40%: A. calamus 25%) with 3 doses i.e T4, T5 & T6 of 50, 75 & 100 mg/kg BW and T7 (Subur Kandungan herb™). Treatment was given every day for 15 days. Results: The results revealed that all treatments affected reproductive hormone and uterine histology profile. However, T1 produced the highest estrogen and progesterone levels, and T2 produced the highest endometrial and myometrium thickness, as well as the number of endometrial glands. Furthermore, the hormonal profile in T1 and histological profile of uterus in T2 were not significantly different from those of T7 group. Conclusions: Combined A. sativum, C. mangga, and A. calamus extracts could be used to increase fertility in female rat. The most effective treatment in this study was dose of 50-75 mg/BW in both compositions.

10aAcorus calamus10aAllium sativum10aCurcuma mangga10aFertility10aRat1 aMuchtaromah, Bayyinatul1 aMuti’ah, Roihatul1 aYusmalasari, Desy, Rahma1 aMardyana, Putri1 aSharmin, Tanjina uhttps://www.phcogj.com/article/1092