02090nas a2200229 4500008004100000245008900041210006900130260001900199300001200218490000700230520137300237653001901610653001801629653003001647653001801677653001901695653002501714100002501739700002801764700002801792856004001820 2020 eng d00aEffect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice0 aEffect of Uncaria gambir and Uncaria sclerophylla on Pulmonary T cFebruary 2020 a192-1960 v123 a

Background: Previous studies on virtual screening on P2Y12 receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. Objective: In this study, we investigated the effect of Uncaria gambir and Uncaria sclerophylla extract on survival rate and bleeding time as antithrombotic in vivo. Methods: Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). U. gambir and U. sclerophylla were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. Results: U. gambir and U. sclerophylla able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group. Conclussion: Both of U. gambir and U. sclerophylla prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.

10aAntithrombotic10aBleeding time10aPulmonary thromboembolism10aSurvival rate10aUncaria gambir10aUncaria sclerophylla1 aSakti, Aditya, Sindu1 aNityasa, Astari, Rachma1 aSaputri, Fadlina, Chany uhttps://www.phcogj.com/article/1090