02695nas a2200313 4500008004100000245009200041210006900133260001900202300001200221490000700233520184200240653001602082653001602098653001502114653001802129653001702147653002102164100001402185700001802199700001802217700001602235700001802251700001502269700001802284700001802302700000502320700001602325856004002341 2020 eng d00aPharmacognostic, Phytochemical and Ethnopharmacological Potential of Cyclamen coum Mill0 aPharmacognostic Phytochemical and Ethnopharmacological Potential cFebruary 2020 a204-2120 v123 a

Background: This review focuses on characterization of Cyclamen coum Mill. (Myrsinaceae), composition and content of biologically active substances presented in the above-ground and underground parts, reporting use of this plant in traditional medicine, predicting possible pharmacotherapeutic effects. Materials and Methods: Various electronic search engines such as Google, Google scholar, scientific literature, electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: Cyclamen L. is classified in the Myrsinaceae family now. It is a typical element of the Mediterranean flora. C. coum. is a species characteristic of the Caucasus and Crimea with rounded leaves and rounded corolla lobes, bright and pink-purple flowers. Chemical composition of biologically active substances of C. coum was described in sufficient detail. C. coum contains saponins (coumoside A, coumoside B, cyclaminorin, deglucocyclamin, cyclacoumin, and mirabilin lactone), sterols (stigmasterol and other related compounds), piperidine alkaloid (2-β-D-glycopyranosyl-2-undecil-3,5-dihydroxy-6-carboxypiperidine), flavonoids, phenols, tannins, cardiac glycosides. Antioxidant, antibacterial, antifungal, and antitumor activities are established for different C. coum extracts. Conclusion: C. coum can be used for the production of potential anticancer, antibacterial and antifungal drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for providing further information to use this medicinal plant in the official medicine. Also, standardization procedures for a crude herbal drug should be developed.

10aCoumoside A10aCoumoside B10aCyclacumin10aCyclamen coum10aCyclaminorin10aDeglucocyclamine1 aDO, Bokov1 aMK, Krasikova1 aEV, Sergunova1 aNV, Bobkova1 aTYu, Kovaleva1 aAA, Bondar1 aAI, Marakhova1 aSL, Morokhina1 a1 aDV, Moiseev uhttps://www.phcogj.com/article/1080