02764nas a2200205 4500008004100000245009800041210006900139260001900208300001200227490000700239520213000246653002202376653002702398653002702425100001602452700001702468700001702485700001602502856004002518 2020 eng d00aCorrection of Toxic Liver Damage with a Multicomponent Herbal Extract in an Animal Experiment0 aCorrection of Toxic Liver Damage with a Multicomponent Herbal Ex cFebruary 2020 a168-1720 v123 a

Background: Digestive diseases constitute a significant part in the overall structure of human diseases. Herbal cholagogues are indicated for a treatment of chronic liver, gall bladder, and bile ducts diseases. The aim of the work is to determine the choleretic effect of a new multicomponent plant extract. Materials and Methods: Multicomponent plant extract was obtained from the following types of plant materials: 300 g of immortelle flowers (Helichrysum arenarium L.), 100 g of tansy flowers (Tanacetum vulgare L.), 100 g of rose fruits (Rosa sp.), 100 g of leaves of common nettle (Urtica dioica L.), 50 g of mint leaves (Mentha piperita L.), 50 g of licorice roots (Glycyrrhiza glabra L.). The extract was standardized by the total flavonoid content. It was calculated and expressed in terms of luteolin and isosalipurposide standards (total flavonoids content: not less than 4% and 15% respectively). The animal experiments being done in 80 nonlinear male rats with initial body weight 180-200 g. In order to study a choleretic effect of multicomponent herbal extract, naive rats recieved the single experimental dose of 250 mg/kg. Pharmacotherapeutic activity was studied in white rats with CCl4-induced hepatitis. Results: Studies indicate a pronounced choleretic effect of the studied plant extract, that is comparable with the effect of “Allochol” in intact rats experiments. The course administration of a per os (peroral) multicomponent plant extract in a dose of 250 mg/kg to white non-linear rats with tetrachloromethane liver damage has a choleretic effect: it increases the rate of bile secretion, stimulates the synthesis and secretion of cholates with bile, and also the excretion of cholesterol and bilirubin. Conclusion: The obtained research results argue the feasibility of using a multicomponent plant extract containing biologically active substances of phenolic nature in the prevention and comprehensive treatment of liver diseases.

10aCholeretic effect10aExperimental hepatitis10aMulticomponent extract1 aEV, Ferubko1 aSM, Nikolaev1 aTD, Dargaeva1 aTD, Rendyuk uhttps://www.phcogj.com/article/1079