01994nas a2200205 4500008004100000245013700041210006900178260001900247300001000266490000700276520132900283653002101612653002601633653001601659653002201675100002501697700002101722700000501743856004001748 2020 eng d00aSubacute Toxicity of Butanol Fraction of Tali Putri Plants (Cassytha filiformis L.) Against Hematology Parameters of White Male Mice0 aSubacute Toxicity of Butanol Fraction of Tali Putri Plants Cassy cFebruary 2020 a25-280 v123 a

Hematotoxicity study of butanol fraction of Cassytha filiformis L. on white male mice has been performed. A total of 12 white male mice were used, and they were divided into four groups. Each group consists of 3 mice. These animals were treated with Cassytha filiformis L. butanolic fraction at several doses of 2.5, 5, and 10 mg/kg for seven days. Hemoglobin value, erythrocytes, platelets, leukocytes, monocytes, lymphocytes, eosinophils, neutrophils, and basophils counts were measured at the 1st, 3rd, and 7th day of treatment. The data of this study were analyzed using two-way ANOVA, followed by Duncan's multiple region tests. The results showed that the doses of butanol fraction did not affect hemoglobin value, erythrocytes, leukocytes, and neutrophils (p >0.1), but it significantly reduced platelet, monocyte, lymphocyte count, and increases eosinophils (p <0.01) counts within their normal limits. There is no influence on the duration of administration and the interaction of dosage, and also the duration of use of the parameters above. This result implies that the Cassytha filiformis butanol fraction at doses of 2.5-10 mg/kg does not affect hematology parameters if it were used for seven days.

10aButanol fraction10aCassytha filiformis L10aHaematology10aSubacute toxicity1 aDillasamola, Dwisari1 aYatursyi, Annisa1 a uhttps://www.phcogj.com/article/1069