02427nas a2200229 4500008004100000245009300041210006900134260001900203300001000222490000700232520170000239653003101939653001701970653002901987100003002016700001802046700002102064700001702085700003202102700002302134856004002157 2020 eng d00aIn vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A549 Lung Cancer Cell Line0 aIn vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A5 cFebruary 2020 a14-190 v123 a

Background: Lung cancer is the one of the leading causes of cancer death. However, current treatments for lung cancer are expensive and show negative side effects. Therefore, the study concerning natural anticancer from plants has intensified. Hibiscus sabdariffa Linn are Indonesian herb plants which have been consumed as a drink, are known to have anticancer activity against several cancer cell lines. However, its potential cytotoxic activity on A549 lung cancer cell line is still unclear. Objective: This study aimed to identify cytotoxic activity of Hibiscus sabdariffa Linn extracts on A549 lung cancer cell line. Materials and Methods: Hibiscus sabdariffa Linn flowers from Tangerang, province of Banten, Indonesia, were macerated in three different solvents: ethyl acetate, ethanol, and n-hexane. Afterwards, cytotoxic activity of Hibiscus sabdariffa Linn extracts on A549 lung cancer cell line were evaluated using MTT assay. There were eight variety of concentration of the extracts, the experiment has been done triplicate for each concentration. The anticancer activity is expressed by IC50 value. Results: Hibiscus sabdariffa Linn extracts in ethanol, ethyl acetate, and n-hexane showed IC50 value of 374.01 μg/mL, 719.28 μg/mL, and 906.57 μg/mL respectively, in which indicated weak cytotoxic activity on A549 lung cancer cell line. Conclusion: Ethanol, ethyl acetate, and n-hexane extracts of Hibiscus sabdariffa Linn are potential to be further developed as natural anticancer agents.

10aA549 Lung Cancer Cell Line10aCytotoxicity10aHibiscus sabdariffa Linn1 aFithrotunnisa, Qotrunnada1 aArsianti, Ade1 aKurniawan, Gerry1 aQorina, Fona1 aTejaputri, Nadzila, Anindya1 aAzizah, Norma, Nur uhttps://www.phcogj.com/article/1067