02370nas a2200229 4500008004100000245017100041210006900212260001800281300001400299490000700313520160600320653001701926653001801943653002301961653002101984653001902005100002002024700002102044700001802065700001702083856004002100 2019 eng d00aEffect of Perillyl Alcohol (POH) A Monoterpene on Lipid Peroxidation and Antioxidant Status in High Fat Diet-Low Dose STZ Induced Type 2 Diabetes in Experimental Rats0 aEffect of Perillyl Alcohol POH A Monoterpene on Lipid Peroxidati cNovember 2019 a1434-14410 v113 a

Aim: The plan of this study was to assess the protective activity of Perillyl alcohol (POH) on the levels of lipid peroxidation (LPO) by-products and antioxidant defense systems in the plasma and other tissues of normal and High Fat Diet-Low Dose Streptozotocin (STZ) induced type 2 diabetes in wistar rats. Materials and Methods: The experimental diabetes was induced in animals by High Fat Diet-Low Dose STZ (35 mg/kg i.p.) injection, and treatment with Perillyl alcohol at the dose of (50mg/kg b.w and 100mg/kg b.w) was continued for 30 days. At the end of treatment period, oxidative stress parameters like lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants including reduced glutathione, Vitamin C and Vitamin E were measured in the plasma and tissues of experimental rats. Results: In untreated diabetic rats an increase was seen in the levels of lipid peroxidation by-products and significant decrease was seen in antioxidant enzymes. Oral administration of Perillyl alcohol a monocyclic monoterpene to diabetic rats for 30 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when the same were compared with the untreated diabetic group. Conclusion: The result of this study indicates that Perillyl alcohol has anti lipid peroxidation and antioxidant status potential in experimental diabetes.

10aAntioxidants10aHigh Fat Diet10aLipid peroxidation10aPerillyl alcohol10aStreptozotocin1 aHassan, Towseef1 aC, Elanchezhiyan1 aNaseer, Insha1 aMarimuthu, S uhttps://www.phcogj.com/article/1045