02301nas a2200205 4500008004100000245012100041210006900162260001800231300001400249490000700263520167600270653002201946653000801968653002301976100001401999700001702013700000502030700002002035856004002055 2019 eng d00aEffect of Fibroblast Growth Factor Combination with Ethanol Extract of Morinda citrifolia L. on Blood Glucose Levels0 aEffect of Fibroblast Growth Factor Combination with Ethanol Extr cNovember 2019 a1558-15620 v113 a

A research has been conducted on the effect of giving Fibroblast Growth Factor (FGF) with Morinda citrifolia L. ethanol extract. This study aims to determine whether the administration of a combination of FGF with ethanol extract of noni fruit can reduce blood glucose levels in diabetes mice induced by alloxan. FGF requires amino acids in regenerating pancreatic β cells, where the amino acids expected from noni fruit can provide a signal response in regenerating pancreatic β cells. In addition, the active substances contained in noni fruit namely xeronine and flavonoid alkaloids can function to reduce blood glucose levels. Test animals were divided into 6 groups, each group consisted of 10 male white mice. Group 1 is a normal control group is a group without any given. Group 2 was a negative control group given 150 mg/kg alloxan. Group 3, 4, and 5 are the treatment groups that are given alloxan and the combination of noni fruit ethanol extract with 3 variations of dose (125; 350; and 1000) mg / KgBW plus FGF dose of 800 mg / kgBW, group 6 is the comparison which is only given FGF alone at a dose of 800 mg / kgBW. The study was conducted for 21 days, observed every 7th, 14th, 21st day using the Easy Touch® GCU digital device. The results of this study showed that administration of noni fruit ethanol extract with FGF was able to reduce blood glucose levels by significance (p <0.05) and based on the percentage calculation of blood glucose levels as much as 44.9% at a dose of 1000 mg / kgBW on the day observations 21st.

10aDiabetes mellitus10aFGF10aMorinda citrifolia1 aS, Dharma1 aY, Rahmawati1 a1 aS, Dillasamolla uhttps://www.phcogj.com/article/1038