02002nas a2200217 4500008004100000245010100041210006900142260001700211300001400228490000700242520131900249653001701568653002401585653001501609653002201624653002501646100002601671700001901697700002801716856004001744 2019 eng d00aFormulation and Characterization of Bitter Melon Extract (Momordica charantia) Loaded Phytosomes0 aFormulation and Characterization of Bitter Melon Extract Momordi cOctober 2019 a1235-12410 v113 a

Objective: Phytosomes are a novel drug delivery system that offers better absorption and bioavailability for extract or phytoconstituents. The aim of this study was developing bitter melon extract load phytosomes with appropriate characteristics for transdermal delivery. Methods: Three formulas were developed, F1, F2 and F3 with weight ratios of extract and phosphatidylcholine were 1: 1, 1: 2 and 1: 3, respectively. Bitter melon fruit was extracted using a maceration method and the marker compounds were determined by high performance liquid chromatography (HPLC) method. Phytosomes were prepared using thin layer method and then characterized, in terms of morphology, particle size distribution, zeta potential and entrapment efficiency. Results: The results of pytosomes characterization reveals that the F3 was the optimal formula. It has a spherical shape, particle size (DV-mean) was 282.3 ± 16.4 nm, zeta potential value at -39.2 ± 0.14 mV and entrapment efficiency of 90.06 ± 1.07 %. Conclusion: Bitter melon extract loaded phytosomes with a weight ratio of extract and phosphatidylcholine 1:3 (F3) was selected as an optimal formula with appropriate characteristics for transdermal delivery.

10aBitter melon10aMomordica charantia10aPhytosomes10aThin layer method10aTransdermal delivery1 aSasongko, Rhatih, Eka1 aSurini, Silvia1 aSaputri, Fadlina, Chany uhttps://www.phcogj.com/article/1024