02160nas a2200217 4500008004100000245012400041210006900165260001700234300001400251490000700265520147300272653002201745653002201767653001701789653002401806653002901830100000501859700002201864700001601886856004001902 2019 eng d00aInhibitory Effects of Different Varieties of Sweet Potato (Ipomoea batatas L.) Tubers Extracts on Lipoxygenase Activity0 aInhibitory Effects of Different Varieties of Sweet Potato Ipomoe cOctober 2019 a1195-11980 v113 a

Background: Sweet potatoes (Ipomoea batatas L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. Objective: This study aimed to determine IC50 value of sweet potato tubers extracts in inhibiting lipoxygenase activity. Methods: Dried tubers of sweet potato were macerated with ethanol 70%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC50 value and total flavonoid contents obtained from each extracts were analyzed statistically. Results: IC50 value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. Conclusion: Total flavonoid contents and IC50 values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.

10aAnti-inflammatory10aIpomoea batatas L10aLipoxygenase10aSweet potato tubers10aTotal flavonoid contents1 a1 aHandayani, Rosita1 aElya, Berna uhttps://www.phcogj.com/article/1000