@article {2085, title = {Anti-inflammatory Potential of Glycoside Flavonoids from Pterocarpus erinaceus Poir. (Fabaceae) Leaves}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {August 2023}, pages = {593-598}, type = {Research Article}, chapter = {593}, abstract = {

Background: Chronic diseases have become one of the leading causes of death worldwide in recent years. Despite tremendous advances in the treatments of diseases, several concerns remain. Those with inflammatory components are alternatively treated or completed in Burkina Faso with medicinal plants. The present study was designed to identify and evaluate the anti-inflammatory potential of glycoside flavonoids from Pterocarpus Erinaceus leaves. Methods: The flavonoids contained in Pterocarpus Erinaceus aerial parts were extracted, identified, and characterized. Sequential soxhlet extraction was subjected to preliminary phytochemical screening, and characterization of isolated flavonoid was done by U.V., I.R., 1H \& 13C N.M.R. and MS. Subsequently, isolates were tested in vitro for their antiinflammatory potential as well as their antioxidant capacities. Results: Five compounds were determined as corresponding to 3{\textquoteright},4{\textquoteright},5,7-tetrahydroxy flavone (luteolin); quercetin-3-O- sophoroside; quercetin- 3-0-β-glucose (isoquercitrin); Kaempferol-3-O-sophoroside and 3,3{\textquoteright},4{\textquoteright},5,7-pentahydroxyflavone-3- rhamnoglucoside (rutin). Concentrations of quercetin-3-O- sophoroside and quercetin-3-0-β-glucose that inhibit 50\% of pro-inflammatory enzymes{\textquoteright} activities were expressed in μg/mL. They were respectively 18.07 {\textpm} 0.78 and 32.27 {\textpm} 2.02 for xanthine oxidase, 1.12 {\textpm} 0.018 and 11.53 {\textpm} 0.52 for lipoxygenase, 26.91 {\textpm} 0.34 and 19.54 {\textpm} 0.25 for acetylcholinesterase. Prevention of the degradation of deoxyribose test gave respectively 19.32 {\textpm} 1.08 μg/mL and 26.21 {\textpm} 2.25 μg/mL for quercetin-3-O- sophoroside and quercetin-3-O- β-glucose while the anti-DPPH free radical potential was 3.41 {\textpm} 0.82 and 2.90 {\textpm} 0.18 μg/ mL. Conclusion: These results may justify the traditional uses of P. erinaceus in treating diseases with an inflammatory component.

}, keywords = {Antioxidant, Compounds, Enzymes, Medicinal plant.}, doi = {10.5530/pj.2023.15.125}, author = {Noufou Ou{\'e}draogo and W. Leila Marie Esther Belem-Kabr{\'e} and A.M. Emmanuel Thiombiano and Tata Kadiatou Traor{\'e} and Lazare Belemnaba and Moussa Ou{\'e}draogo and Innocent Pierre Guissou} } @article {243, title = {Inhibition Kinetics of Acetylcholinesterase and Phosphatases by the Active Constituents of Terminalia arjuna and Tamarindus indica in the Cerebral Ganglion of Lymnaea acuminata}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {February 2017}, pages = {148-156}, type = {Original Article}, chapter = {148}, abstract = {

Introduction: Paper demonstrates effect of the active molluscicidal components arjunolic acid (Terminalia arjuna bark) and procynadine (Tamarindus indica seed) on the activity of acetylcholinesterase (AChE) and phosphatases (ACP/ALP) in the cerebral ganglion of snail Lymnaea acuminata. Materials and Methods: Kinetics of AChE/ACP/ ALP inhibition in the cerebral ganglion of snail Lymnaea acuminata was studied via in vivo (40\% and 80\% of 96 h LC50) and in vitro treatments (0.3 g to 7.0 g) of the column purified fractions, arjunolic acid and procynadine. Results: In vivo exposure of procynadine and arjunolic acid significantly inhibit acetylcholinesterase (AChE), acid phosphatase (ACP) and alkaline phosphatase (ALP) activities in the cerebral ganglion of L. acuminata exposed to 80\% of 96h LC50. In in vitro treatment maximum inhibition in AChE/ACP/ALP activities in the cerebral ganglion of snail were noted when exposed to 7.0 g of arjunolic acid and 0.9 g of procynadine. Column purified fraction of T. arjuna bark and T. indica seed caused non-competitive and uncompetitive inhibition of AChE activity, respectively. Column purified fraction and arjunolic acid of T. arjuna bark caused uncompetitive inhibition of ACP while column purified fraction and procynadine of T. indica seed caused competitive inhibition. Competitivenon- competitive inhibition of ALP activity in the cerebral ganglion of L. acuminata was observed after treatment of column purified active components of both plants. Conclusions: The molluscicidal activity of T. arjuna bark (arjunolic acid) and T. indica seed (procynadine) against snail L. acuminata is due to the inhibition of AChE/ACP/ ALP. Their inhibition kinetics against AChE/ACP/ALP, were different in cerebral ganglion of snail.

}, keywords = {Arjunolic acid, Enzymes, Lymnaea acuminata, Procynadine, Tamarindus indica, Terminalia arjuna}, doi = {10.5530/pj.2017.2.25}, url = {http://phcogj.com/fulltext/292}, author = {Neelam Soni and Dinesh Kumar Singh and Vinay Kumar Singh} }