@article {1920, title = {Ameliorative Effects of Moringa (Moringa Oleifera Lam.) Leaves Extract on Lead-Induced Oxidative Stress, Hepcidin and δ-Alad Levels in Rat{\textquoteright}s Blood}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {December 2022}, pages = {856-862}, type = {Research Article }, chapter = {856}, abstract = {

Introduction: Lead (Pb) is a toxic heavy metal that cause a lot health problem. Blood, especially hemoglobin and erythrocyte, is the main target of lead poisoning. Literatures explain that moringa has phytochemical contents to reduce heavy metal poisoning. This study aimed to examine ameliorative effects of moringa leaves extract on oxidative stress, hepcidin increasement and δ-alad level decline induced by lead poisoning in the blood of rat model. Methods: This study was completely randomized posttest-control group design. Forty-eight males Rattus norvegicus Wistar strain rat were divided into 4 groups. The control group or G0 (given Pb orally doses of 750 mg/kgBW/day for 7 days and was not given 50\% ethanol extract of moringa leaves/MLEE). Three treatment groups (G1, G2 and G3), all were given Pb at a dose of 750 mg/kgBW/day orally for 7 days, followed by administration of MLEE for 14 days at a dose of 250 mg/kgBW/day, 500 mg/kgBW/day and 1,000 mg/kg/day orally, respectively. Blood samples were taken one day after 14 days of MLEE treatment. Pb levels was examined by AAS and δ-ALAD levels, GSH levels, MDA levels and hepcidin levels examined by ELISA. Results: MLEE doses 1,000 mg/kgBW/day for 14 days increased δ-ALAD levels, GSH levels, hepcidin levels and reduce MDA levels significantly compared to the control group. Conclusion: Moringa leaves ameliorate lead-induced poisoning by reducing oxidative stress, declining hepcidin, and increasing δ-ALAD in the blood of male Rattus norvegicus Wistar strains rats. Moringa leaves is beneficial to address Pb poisoning in the blood through antioxidants, anti-inflammation, and improving δ-ALAD level in the blood of Wistar strain rats.

}, keywords = {Blood, Hepcidin, Lead poisoning, Moringa, Oxidative stress., δ-ALAD}, doi = {10.5530/pj.2022.14.179}, author = {Agung Saprasetya Dwi Laksana and Harianto Notopuro and Arifa Mustika} } @article {217, title = {A Review of Pharmacognostical Studies on Moringa oleifera Lam. flowers}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {December 2016}, pages = {1-7}, type = {Review Article}, chapter = {1}, abstract = {

Moringa oleifera Lam. of the family Moringaceae, popularly called \‘miracle tree\’ is a native of sub Himalayan tracts of Northern India and is widely cultivated in tropical and subtropical regions. Research on Moringa mainly pivoted around its leaves and seeds because of their immense nutraceutical potential but recently there is a greater interest in flowers too, mostly inspired by the positive outcomes of several pharmacognostical studies on flowers. Moringa flower is a rich reservoir of bioactive phytochemicals and crude flower extracts showed promising antibacterial, antifungal, anti larval, antioxidant, anti inflammatory and anticancer properties. This review concisely presents the various phytochemicals identified and isolated as well as the various bioassays employed to validate the therapeutic potential of flower. It is prepared after a detailed search on Google scholar. Reports on Moringa oleifera flower were sorted and tabulated based on the bioassays performed and solvents used for extraction. A grading pattern is adopted for comparing efficiency of different extracts in eliciting bioactivities. Many of these studies are at the preliminary stage but two of them present advanced mechanisms. First is the presence of a proteinaceous larvicidal compound \‘MoFTI\’ in the flower capable of inhibiting larval trypsin of Aedes aegypti. The second describes flower extract\’s anti inflammatory mechanism effecting via NF-KB pathway and consequent suppression of inflammatory mediators\’ activation, but short of identifying lead compound/compounds behind this effect. Thus authors suggest further studies to elucidate the detailed mechanisms, identify and isolate the active compound or compounds of synergism behind the many therapeutic potential of the Moringa flower extracts.

}, keywords = {Bioactivity, Bioassay, Extracts, Flower, GCMS, Moringa, Phytochemicals, Therapeutic}, doi = {10.5530/pj.2017.1.1}, url = {/files/PJ-9-3/10.5530pj.2017.1.1}, author = {Tom Mathew Kalappurayil and Benny Pulinilkkumthadathil Joseph} }