@article {1425, title = {Evaluation of Antioxidant and Anticancer Activity of Myristica fragrans Houtt. Bark}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {780-786}, type = {Research Article}, chapter = {780}, abstract = {

This study aims to evaluate the antioxidant and anticancer activity of secondary metabolite compounds from Myristica fragrans Houtt. (nutmeg) bark using n-hexane extract based on DPPH radical scavenging and microculture tetrazolium salt (MTT) assay. The chemical structural analysis using NMR, FTIR, and LC-MS spectroscopy confirmed and identified the structure of isolated compound namely (2E)-5(2z.4E)-hexa-2,4,-dio-zyl)-2propylcyclohexanol (C18H30O4) for the first time which is corresponding for the excellent antioxidant and anticancer activity against MCF-7 cell lines with the IC50 value of 99.76 and 10.75 ppm, respectively.

}, keywords = {Anticancer, Antioxidant, Bark, n-hexane extract, Nutmeg (Myristica fragrans Houtt)}, doi = {10.5530/pj.2021.13.99}, author = {Binawati Ginting and Mustanir and Nurdin and Maulidna and Murniana and Safrina} } @article {1604, title = {Phytochemical Analysis, Antioxidant, and Anti-Microbial Activities of Suaeda vermiculata n-Hexane Extract in Comparison to the Plant{\textquoteright}s Hydrodistilled Volatile Oil}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {853-859}, type = {Original Article}, chapter = {853}, abstract = {

Background: Suaeda vermiculata, a halophyte found in central Saudi Arabia, used as a remedy for jaundice, liver diseases, and viral infection. Study aim: Chemical identification and biological evaluation for the n-hexane extract of S. vermiculata. Methods: An assay of the antimicrobial and antioxidant potentials and contents of the volatile oil and n-hexane extract of the plant{\textquoteright}s aerial parts were analyzed through GC-MS analysis. Results: A total of 24 constituents representing 73.74 \% of the n-hexane extract were identified wherein bornyl acetate, γ-elemene, and phytol were major ratio. The n-hexane extract inhibited DPPH-radicals inhibitions at 27\% efficiency at 10 mg/ml concentration which was lower than the volatile oil DPPH-reactivity. The antimicrobial activity of n-hexane extract was relatively weaker than the volatile oil, except against Candida albicans that showed IZD values of 19 mm with MIC value at 5.2 mg/ml for the volatile oil while IZD value of 26 mm and MIC at 4.7 mg/ml was observed for the n-hexane extract. Conclusion: Despite high extractive value, the n-hexane as a solvent is not recommended for extraction as the oxygenated-terpenic components, considered responsible for antioxidant and antimicrobial activities were not fully extracted. The n-hexane extract which showed potent inhibition of C. albicans can be a source for further investigation for bioactivities of its constituents.

}, keywords = {Antimicrobial activity, antioxidant activity, n-hexane extract, Suaeda vermiculata, Volatile oil}, doi = {10.5530/pj.2021.13.109}, author = {Mohsen S Al-Omar} } @article {203, title = {GC-MS Analysis of n-hexane Extract of Stem Bark of Symplocos crataegoides Buch.-Ham. ex D. Don}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {September 2016}, pages = {520-524}, type = {Original Article}, chapter = {520}, abstract = {

Context: The stem barks of the plant Symplocos crataegoides Buch.-Ham. ex D. Don (syn. Symplocos paniculata (Thunb.) Miq.), Fam. Symplocaceae is extensively used in Indian medicine under the names of Lodhra/Patikalodhra. Mainly it is used to cure uterine complaints, vaginal and menstrual disorders. Aim: To investigate the phytochemicals from the n-hexane extract of the stem bark of Symplocos crataegoides Buch.-Ham. ex D. Don., using GC-MS analysis. Materials and Methods: Stem bark of S.crataegoides was extracted by Soxhlet extraction method using n-hexane. The extract was injected by splitless injection mode into the GC MS 5975 C Agilent equipped with a QP- 5000 (quadrupole) Gas Chromatography - Mass Spectrometer. Results: Identification of 57 compounds from n-hexane extract. Those compounds were identified by close matches with standard MS spectra and compared with NIST - 11 and WILEY library data. Undecane (7.51\%) was found as major compound followed by Isopropyl myristate, Dodecane, 1,2,4-trimethyl-benzene, Octacosane, 2-methyl-decane, 2-ethyl-1,2-dimethyl-benzene, 1,2,3,5- tetramethyl-benzene etc., other constituents were found to be in traceable quantities. Conclusion: GC-MS analysis of S. crataegoides revealed certain interesting facts of presentation of various phytoconstituents in the stem bark. The presence of various phytoconstituents contributes to the medicinal activity of the plant.

}, keywords = {GC-MS analysis, n-hexane extract, Patikalodhra, Symplocos Crataegoides}, doi = {10.5530/pj.2016.6.2}, author = {Nartunai Govindarajan and Uma Maheswara Reddy Cheekala and Shantha Arcot and Susikumar Sundaramoorthy and Ramasamy Duraisamy and Ilavarasan Raju} }