@article {2397, title = {Clinicopathological Analysis of Mucinous Ovarian Tumors at a Single Center in Indonesia, 2019-2023}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {October 2024}, pages = {1138-1142}, type = {Research Article}, chapter = {1138}, abstract = {

Background: Mucinous ovarian tumors are a rare subtype of epithelial ovarian tumors, accounting for approximately 3\% of all cases. These tumors exhibit unique clinical and pathological characteristics, with a particularly poor prognosis in advanced stages due to low responsiveness to platinum-based chemotherapy. Objective: This study aims to analyze the relationships between clinicopathological characteristics in patients with mucinous ovarian tumors treated at a single center in Indonesia between 2019 and 2023. Materials and Methods: A correlational study from March to June 2024 analyzed patients with confirmed mucinous ovarian tumors in Indonesia, focusing on age, histopathological grade, FIGO stage, CA-125 levels, tumor size, and metastasis presence. Results: A study of 123 mucinous ovarian tumor patients found that 57.7\% were over 40. Histopathological analysis revealed 21.1\% were benign, 26\% borderline, and 52.8\% malignant. Patients over 40 had more malignant tumors, advanced-stage disease, and omental metastasis. A significant correlation was found between malignant histopathology and advanced FIGO stage, as well as between advanced FIGO stage and both lymph node and omental metastasis. Tumor size was associated with elevated CA-125 levels and bilateral tumors. Conclusion: Mucinous ovarian tumors in patients over 40 years old are more likely to be malignant, present at an advanced stage, and involve omental metastasis. Malignant histopathological results are associated with advanced FIGO stages, which in turn are linked to lymph node and omental metastasis. Tumors larger than 10 cm tend to have elevated CA-125 levels.

}, keywords = {Clinicopathological characteristics, Indonesia, Mucinous ovarian tumors, Single center}, doi = {10.5530/pj.2024.16.186}, author = {Bayu Aditya Nugraha and Brahmana Askandar Tjokroprawiro} }