@article {1292, title = {Resveratrol: Latest Scientific Evidences of its Chemical, Biological Activities and Therapeutic Potentials}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1779-1791}, type = {Review Article}, chapter = {1779}, abstract = {

Background: Resveratrol is a non-flavonoid polyphenol possesses many biological properties with great potential to develop into various products. In order to cure a wide variety of diseases, resveratrol has attracted a great deal of attention for medicinal purposes. Objective: The present review aimed to provide a comprehensive literature summary of latest scientific evidences on the chemistry, biological properties and therapeutic potentials of resveratrol. Methods: To complete this review, relevant literatures were collected from several scientific databases, including Google Scholar, Pubmed and ScienceDirect, using keywords {\textquotedblleft}source{\textquotedblright}, {\textquotedblleft}chemistry{\textquotedblright}, {\textquotedblleft}bioavailability{\textquotedblright}, {\textquotedblleft}pharmacokinetics{\textquotedblright}, {\textquotedblleft}isolation{\textquotedblright}, {\textquotedblleft}anticancer{\textquotedblright}, {\textquotedblleft}analgesic{\textquotedblright}, {\textquotedblleft}antiinflammatory{\textquotedblright}, {\textquotedblleft}antidiabetic{\textquotedblright}, {\textquotedblleft}nephroprotective activity{\textquotedblright}, {\textquotedblleft}neuroprotective activity{\textquotedblright}, {\textquotedblleft}antiobesity{\textquotedblright}, {\textquotedblleft}cardioprotective effects{\textquotedblright}, {\textquotedblleft}antioxidant{\textquotedblright}, {\textquotedblleft}anti-aging{\textquotedblright} with resveratrol. After a detailed screening process for inclusion and exclusion, the information obtained was summarised. Results: The information on the source, chemistry, bioavailability, biological and therapeutic potentials of resveratrol were tabled. In various pathological conditions, resveratrol can be considered as powerful antioxidants along with multidimensional molecular targets such as NF-ҡB, MAPK, AMPK, SIRT-1, Nrf-2, m-TOR, PI3K/Akt and PPAR-γ signaling pathways. Conclusion: Based on the existing knowledge, we may believe that resveratrol has a significant therapeutic potential for the treatment of various diseases. To accelerate the development and utilization of resveratrol as promising products, in-depth studies should be focused on exploiting its properties and developing phytopharmaceuticals.

}, keywords = {Bioavailability, Inflammatory cytokines, Molecular targets, Pharmacology, Resveratrol, Toxicity}, doi = {10.5530/pj.2020.12.240}, author = {Nur Mursyida Saad and Mahendran Sekar and Siew Hua Gan and Pei Teng Lum and Jaishree Vaijanathappa and Subban Ravi} } @article {167, title = {Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty) compared to Curcumin in Wistar rats}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {380-384}, type = {Original Article}, chapter = {380}, abstract = {

Objective: To evaluate anti-inflammatory activity of bioenhanced turmeric formulation (BCM-95) compared to commercial Curcumin formulation (Curcuminoids 95\%) in Carrageenan-induced acute inflammatory model. Materials and Methods: Thirty six Wistar rats were divided into six groups-Normal control (2 ml of vehicle), Standard control (Indomethacin 10 mg/kg), 2 doses of BCM 95 (10 and 20 mg/kg) and Curcuminoids 95\% (10 and 20 mg/kg). Paw volume was measured using a digital plethysmometer. Vehicle or test drugs were given to rats 30 min before carrageenan administration. Baseline paw volume reading (V0) was noted just prior to administration of 0.1 ml of 1\% carrageenan to right hind paw of the rat. Test paw volume readings (Vt) were measured at 30, 60, 120, 180, 240, 300 and 360 min, after carrageenan injection. Oedema expressed as increased paw volume (vt-v0) was noted and percentage inhibition of oedema was calculated for all treatment groups. Statistical analysis: Difference between groups were analyzed with ANOVA followed by Tukey test. Results: All treatment groups demonstrated significant (p\<0.05) anti-inflammatory activity (oedema suppression) compared to normal control. Anti-inflammatory activity of BCM 95 treated groups were comparable to standard control group except at certain time points, whereas the same activity at all-time points with Curcuminoid 95\% treated groups were significantly less than standard control group. Percentage inhibition of paw oedema was maximum with standard control group followed by BCM 95 treated groups followed by Curcuminoid 95\% treated groups. Conclusion: BCM 95 treated groups showed significant anti-inflammatory activity compared to Curcuminoid 95\% treated groups.

}, keywords = {Anti-Inflammatory agents, Bioavailability, Curcumin, Inflammation, Wistar rats.}, doi = {10.5530/pj.2016.4.11}, author = {Sayeli Vinaykumar and Urval Pundarik Rathnakar and Ullal Sheetal Dinkar and Kamath Priyanka and Tiwary Gaurav and Shenoy Ashok Kudgi and Revappala Sekhar Nishith} }