@article {2598, title = {The Effectiveness of Enteral Administration of Binahong Leaf Extract (Anredera cordifolia (Tenore) Steenis) on Blood Glucose Levels, MDA, and NGF in Wistar Rats with Diabetic Neuropathy Model}, journal = {Pharmacognosy Journal}, volume = {18}, year = {2026}, month = {June 2026}, pages = {107-112}, type = {Original Article}, chapter = {107}, abstract = {

Background: Chronic hyperglycemia causes oxidative stress in the peripheral nervous system, which leads to the development of diabetic neuropathy. Free radicals initiate lipid peroxidation of membranes and produce malondialdehyde (MDA). Reduced Nerve Growth Factor (NGF) in diabetes indicates significant neuronal abnormalities. Binahong (Anredera cordifolia (Ten.) Steenis) belongs to the Basellaceae family and possesses therapeutic effects, making it a promising herbal remedy for the development of treatments for diabetic neuropathy. Objective: To determine the effectiveness of binahong leaf extract (Anredera cordifolia (Tenore) Steenis) in lowering blood sugar and MDA levels and increasing NGF in Wistar rats with diabetic neuropathy. Methods: This study was an experimental study using rats with a randomized control trial with a post-test control only design. The study population consisted of 36 Wistar rats divided into 6 groups randomly, which were then induced with diabetic neuropathy via streptozotocin injection at 65 mg/kg. Complete data collection was conducted, followed by blood glucose levels, MDA, and NGF measurements, and data analysis. Results: There were significant differences (p\<0.05) in blood glucose levels, MDA, and NGF between the normal group, the 50 mg/kg binahong leaf extract group, the 100 mg/ kg radish extract group, and the 200 mg/kg group compared to the negative control group. This indicates that binahong leaf extract, starting at a dose of 50 mg/kg, can reduce blood glucose levels and MDA while increasing NGF. Conclusion: Binahong leaf extract (Anredera cordifolia (Tenore) Steenis) is effective in lowering blood glucose levels and MDA levels while increasing NGF in a rat model of diabetic neuropathy.

}, keywords = {Anredera cordifolia, blood glucose levels, Diabetic neuropathy, Malondialdehyde, Nerve Growth Factor, Wistar Rats}, doi = {10.5530/pj.2026.18.123}, author = {Ana Fresia and Gusbakti Rusip and Ade Indra Mukti and Ali Napiah Nasution} } @article {2260, title = {Anxiety Levels, Cortisol, Blood Gluc Ose and Sodium Levels in Working Wives: Comparison Between Husbands Who Were Hospitalized and Husbands Who Were Not Hospitalized}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {April 2024}, pages = {382-387}, type = {Research Article}, chapter = {382}, abstract = {

Background:\ Anxiety affects balance and physiological changes in the body. The research aims to investigate the comparison of anxiety levels, blood cortisol levels, blood glucose levels and blood sodium levels between working wives of husbands who are hospitalized and working wives of husbands who are not hospitalized. Methods: The research design uses statistical group comparison. The research subjects were 40 people divided into 2 groups, namely 20 subjects, working wives, husbands who were hospitalized, 20 subjects, working wives, husbands, who were not hospitalized. Data was collected using the HARS (Hamilton Anxiety Rating Scale) questionnaire instrument, laboratory examination of blood cortisol levels, blood glucose levels and blood sodium levels. Results: Unpaired t test with a significant value of p \< 0.05 if the data is normally distributed or Mann Whitney U Test with a significant value of p \< 0.05 if the data is not normally distributed was carried out to analyze the comparison of anxiety levels, blood cortisol levels, sugar levels blood and blood sodium levels. Data processing with the help of statistical software. The results of the analysis showed that there were differences in anxiety levels (p\<0.05), blood cortisol levels (p\<0.05) and blood glucose levels (p\<0.05) but there were no differences in blood sodium levels (p\>0.05). between working wives whose husbands are hospitalized and working wives whose husbands are not hospitalized. Conclusion: blood cortisol levels and blood sugar levels in working wives of husbands who were hospitalized were higher than working wives of husbands who were not hospitalized and based on statistical tests, significant differences were found in HARS values, blood cortisol levels and blood sugar levels between the group of working wives whose husbands were hospitalized. hospitalized and the wife works, the husband is not hospitalized.

}, keywords = {Anxiety, blood cortisol levels, blood glucose levels, blood sodium levels, HARS, working wife}, doi = {10.5530/pj.2024.16.59}, author = {Rudi Mahruzar and I Nyoman Ehrich Lister and OK Yulizal and Hamzah Shatri and Gusbakti Rusip} }