@article {1696, title = {Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {December 2021}, pages = {1648-1655}, type = {Research Article}, chapter = {1648}, abstract = {

The methanolic extract of leaves of C.dicoccum was evaluated for its hepatoprotective activity against paracetamol induced hepatotoxicity since it is reported to cause oxidative stress in the animal thereby altering the enzymatic levels. Fresh leaves were collected, shade dried and extract was prepared by cold maceration followed by drying in a rota-vapour using methanol to obtain MECD as a sticky semi-solid mass. Thirty rats were taken and divided into 5 equal groups where, Group I, II, and III served as Normal Control, Negative control (PCM 3g/kg), and Positive control (Silymarin 200mg/kg) respectively; whereas, Group IV and V served as test groups where the rats were pre-treated orally with MECD 200mg/kg and 400mg/kg respectively for six days before administering PCM. On the 8th day all groups except Group I was administered with PCM (3g/kg). 48 hours post PCM induction, the animals were anesthetized, blood samples were obtained via retro-orbital sinus plexus and then the rats were sacrificed. The serum was assessed for the evaluation parameters like AST, ALT, ALP, and bilirubin levels. Apart from these; SOD, CAT, and MDA levels were also evaluated and it was concluded that treatment with MECD restored the levels to normal thereby exhibiting hepatoprotective activity. Moreover, histopathological evaluation was carried out to assess the liver for inflammation, infiltration, or necrosis where the MECD treated rats showed promising results.

}, keywords = {Antioxidant enzymes, Canthium dicoccum, Hepatoprotective activity, Liver markers, Paracetamol.}, doi = {10.5530/pj.2021.13.212}, author = {Ravi Kumar Vakkalagadda and Parameshwar Ravula and Kondapuram Parameshwar and Kaspa Saraswathi and P Sindhuri and Rajala Srikala and Kosika Sandeep} } @article {485, title = {Nephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {136-147}, type = {Original Article}, chapter = {136}, abstract = {

Introduction: Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: Lantana camara and Cucurbita pepo and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of L. camara by HPLC-ESI- MS. Methods: Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. Results: The defatted methanolic extract and ethyl acetate fraction of L. camara showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of L. camara extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. Conclusion: The phytochemical constituents of L. camara are responsible for their nephroprotective activity.

}, keywords = {Antioxidant enzymes, Ascorbic acid, Creatinine, Flavonoids, Histological studies, Phenyl etanoid.}, doi = {10.5530/pj.2018.1.24}, url = {http://fulltxt.org/article/410}, author = {Heba Abdel-Hady and Mortada Mohamed El-Sayed and Afaf Ahmed Abdel-Hady and Maher Mahmoud Hashash and Ahmed Mohamed Abdel-Hady and Tarek Aboushousha and El-Sayed Saleh Abdel-Hameed and Ezzat El-Sayed Abdel- Lateef and Eman Abdalla Morsi} } @article {155, title = {Evaluation of Healing Potential of Achyranthes aspera L. (Amaranthaceae) seeds in excision, incision, dead space and burn wound model-An in-vivo Study}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {February 2016}, pages = {300-306}, type = {Original Article}, chapter = {300}, abstract = {

Objective: The present study deals with the in vivo investigation of healing properties of Achyranthes aspera L. seeds in excision, incision, dead space and burn wound model. Methods: Preliminary phytochemical tests were performed to find out different phytoconstituents in the test extract. Acute toxicity test were performed to find any abnormalities in mice. Wound healing activities were performed on Wistar rats using excision, incision, dead space and burn wound model. The percentage of wound closure and period of epithelization were recorded for excision and thermal burn wound model, whereas the breaking strength was recorded in incision wound model. In dead space wound model, hydroxyproline content and granulation tissue antioxidant enzymes like SOD and CAT were estimated. Results: The phytochemical investigation showed the presence of alkaloids, carbohydrates, tannins, flavonoids, saponins, lipids and triterpenoids. There were no abnormalities observed in the acute toxicity test. The results of wound healing activity revealed that EEAAS treated group showed an enhanced wound contraction and epithelization period in both excision and burn wound models, whereas in incision wound model the wound breaking strength was significantly increased in extract treated group compared to control. The histology of the skin of healed excised wound showed restoration to almost the normal architecture of the skin in extract treated group compared to the control. In dead space wound model, enhanced antioxidant enzymes and connective tissue markers were observed in the extract treated group. Conclusion: Thus the results conclude that EEAAS possesses potent wound healing properties with a reasonable safety profile.

}, keywords = {Achyranthes aspera L., Antioxidant enzymes, Hydroxyproline, Povidone iodine, Silver sulfadiazine, Thermal burn.}, doi = {10.5530/pj.2016.3.20}, author = {Sumanta Mondal and Debjit Ghosh and Seru Ganapaty and Motati Sushrutha Reddy and Karipeddi Ramakrishna} }