@article {1429, title = {Fenugreek (Trigonella Foenum-Graecum) and its Active Compounds: A Review of its Effects on Human Health through Modulating Biological Activities}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {813-821}, type = {Review Article}, chapter = {813}, abstract = {

Fenugreek seed are rich sources of various essential compounds and such components shows a significant role in the diseases cure and management through its anti-inflammatory, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, nephroprotective and anti-microbial activity. Moreover, fenugreek seed is a rich source of antioxidant and such potentiality inhibit the pathogenesis of diseases through free radical scavenging activity. Besides, fenugreek and its active compound shows role in tumour inhibition through modulating various genes activity including induction of apoptosis, tumour suppressor gene and inhibition of tumor necrosis factor. This review comprehensively summarizes the role of fenugreek seeds in health management through modulating various physiological and biochemical activities, along with special emphasis on in vitro and in vivo study.

}, keywords = {Anti-cancer activity, Anti-inflammatory, Anti-oxidant, Fenugreek, Health management, Trigonella foenum-graecum}, doi = {10.5530/pj.2021.13.103}, author = {Saleh A Almatroodi and Ahmad Almatroudi and Mohammed A Alsahli and Arshad Husain Rahmani} } @article {1268, title = {Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1463-1474}, type = {Review Article}, chapter = {1463}, abstract = {

Throughout history, many plants and their products have been widely used as medicines for the prevention and treatment of different diseases in many cultures. Garlic (Allium sativum), is commonly used as a spice and traditionally used for its medicinal value since ancient times. Recent studies support the effects of garlic and its extracts in a wide range of applications. Due to the presence of sulfur containing compounds, high trace mineral content and enzymes, garlic has been reported to have implications in disease management and play a role as anti-diabetic, anti-microbial, anti-obesity, anti-oxidant and anti-tumor, dyslipidaemia effect, neuroprotective, cardio-preventive and photo-protection effects. It contains various active compound such as allicin, ajoene, diallyl disulfide and S-allyl-cysteine that modulates various biological cascades and prevent the pathogenesis. This review illustrates the role of garlic and their active ingredients in the health management based on in vivo and in vitro studies.

}, keywords = {Ajoene, Allicin, Anti-cancer, Anti-inflammatory Effect, Anti-oxidant, Diallyl disulfide, Garlic}, doi = {10.5530/pj.2020.12.201}, author = {Faris Alrumaihi} } @article {1207, title = {Paronychia argentea: A Critical Comprehensive Review on its Diverse Medicinal Potential and Future as Therapeutics}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1172-1179}, type = {Review Article}, chapter = {1172}, abstract = {

Background: Paronychia argentea has been used since long as a traditional medicine for the treatment of diabetes, kidney stones, anti-microbial and many other human diseases. However, the plant has not been explored much. In the present scenario of drug resistance and toxicity associated with available drugs, there is a need for elaborated studies of plants like Paronychia argeneta which had been used as folk medicines. Aim and Objectives: The present article is focused on reviewing the ethnopharmacology, phytochemistry, traditional usage, biological activities, of Paronychia argentea which has been used in traditional medicinal system for ages. The aim of the study was to assess the ethnopharmacological usage of this plant and to explore therapeutic potentials and future opportunities for research. Materials and Methods: Information on the traditional usage and studies of the Paronychia argentea was gathered from from various journals, MSc dissertation, conference abstract, local books. Various search engines including Google Scholar, Baidu Scholar, Elsevier, ACS, Pubmed, Web of Science, CNKI and EMBASE were used to collect the information along with libraries. Results: Paronychia argentea has played an important role in traditional medicines in Algeria, Portugal, Israel and Jordan. The aerial parts of this plant are used as diuretics in Algerian traditional medicines and are used as antiurolithiasis. Leaf decoction of this plant is also used as diuretic. Paronychia argentea has been used as analgesic, treatment of stomach ulcer, anorexia, and flatulence in Portugal. Scientific studies on extracts of Paronychia revealed a wide range of pharmacological activities including anti-microbial activity, anti-oxidant, nephroprotective activity. Moreover, few reports have given contradictory data for usage of Paronychia when compared with its traditional usage. As in the case of alpha-amylase inhibitory efficacy of PA, it was observed that PA inhibits alpha-amylase activity but later on it was proven that PA does not have a hypoglycemic effect. Main bioactive metabolites present in this plant include alkaloids, flavonoids, volatile oils, etc. Conclusions: Based on this review, there are evidences from various studies regarding pharmacological effects of this plant as nephroprotective, anti-oxidant, anti-microbial activity. Some indications from in vitro studies have confirmed the inhibitory activity of this plant extract against alpha amylase enzyme. The available literature showed that most of the activities of the Paronychia can be accredited to the flavonoids present in them. Data regarding mechanisms of action of this plant along with pharmacokinetics, toxicology studies is still limited, which indicate the need of such studies for the clinical usage of this plant.

}, keywords = {Anti-microbial, Anti-oxidant, Bioactivity, Herbal medicine, Nephroprotective, Oxidative stress, Paronychia argentea, Therapeutic value, Ulcerative colitis}, doi = {10.5530/pj.2020.12.165}, author = {Vishnu Priya Veeraraghavan and Sardar Hussain and Janardhana Papayya Balakrishna and Surapaneni Krishna Mohan} } @article {1208, title = {Pharmacognostic, Phytochemical and in vitro Biological Evaluation of Blepharis repens (Vahl) Roth}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {952-961}, type = {Original Article}, chapter = {952}, abstract = {

Blepharis repens (Vahl) Roth of Acanthaceae family, commonly known as Hadsan in Marathi and Haridachchu in Kannada, is threatened species due to exploitation from natural habitat. Objectives: The objective of present study is to establish scientifically well evaluated pharmacognostic and biological efficacy parameters. Methods: Microscopical parameters of leaf, root and stem are evaluated. Powder microscopy, physicochemical analysis, elemental analysis, fluorescence analysis, preliminary phytochemical screening and estimation of major phytoconstituents of whole herb powder are carried out. In vitro biological evaluation of Blepharisrepens carried out for antioxidant potential by DPPH method, in vitro anticancer activity by SRB assay and antimicrobial efficacy by both agar well diffusion and bioautography methods. Results: Morphologically, roots are cylindrical and elongated, leaf has symmetric base, entire margin, acute apex while stem is cylindrical, elongated. Microscopic evaluation reveals that both leaf and stem are covered with trichomes. Leaf has unicellular uniseriate trichomes while stem has multi-cellular uniseriate covering trichomes. Physicochemical evaluation revealed that total ash, acid insoluble ash and water-soluble ash values 13.85 7.7 and 3.1\% respectively. Petroleum ether, alcohol and water extractive values found 0.84\%, 1.64\%, and 3.52\% respectively. Loss on drying value is found 3.43\%. Element analysis of whole herb confirms presence of nitrogen, sulphate and carbonate. Fluorescence tests are performed by treatment with different acids and alkalis and exposure to ultraviolet light. Phytochemical screening shows presence of carbohydrates, alkaloids, tannins, flavonoids and saponins. Estimation of phytochemicals like carbohydrate, alkaloid, tannin and flavonoid found 5.78\%, 1.43\%, 5.7\% and 1.48\% respectively. Biological evaluation reveals that plant has significant antioxidant and antimicrobial activity while plant is devoid of in-vitro anticancer activity against human leukemia cell line HL-60.

}, keywords = {Anti-cancer, Anti-microbial, Anti-oxidant, Bioautography, Blepharisrepens, HL-60}, doi = {10.5530/pj.2020.12.135}, author = {Sharada L Deore and Poonam B Bhansali and Bhushan A Baviskar} } @article {794, title = {Evaluation of Pharmacological Properties of Caesalpinia bonducella Seed and Shell Extract}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {January-2019}, pages = {150-154}, type = {Original Article}, chapter = {150}, abstract = {

Background: Caesalpinia bonducella L. is a medicinal plant belonging to the family Caesalpiniaceae. It is a prickly shrub widely distributed all over the world especially in Indian tropical regions such as Kerala, Andaman and Nicobar Islands and Sri Lanka. There are claims that its leaves or seeds/ seed kernel possess antipyretic, antidiuretic, antibacterial, antiviral, antiestrogenic and antidiabetic activities Due to the above properties several preparations of the plant were used in folk medicine. Materials and Methods: The aqueous extract of Caesalpinia bonducella nut containing the seed and the shell, has been evaluated for qualitative analysis of secondary metabolites (tannis, flavonoids, alkaloids, saponins, coumarins, quinone and phenols), in-vitro anti -inflammatory, anti-diabetic assay, antioxidant, antimitotic and antimicrobial activity. The studies were carried out using HRBC membrane stabilization, inhibition of alpha amalyse enzyme, DPPH method, green gram growth inhibition, agar diffusion method respectively. Results: Our results indicate the presence of Alkaloids, Flavanoids and Saponins. We report in our study the antidiabetic, anti-inflammatory, anti-oxidant, anti-microbial and antimitotic activity of Caesalpinia bonducella.

}, keywords = {Anti-diabetic, Anti-inflammatory, Anti-mitotic, Anti-oxidant, Caesalpinia bonducella}, doi = {10.5530/pj.2019.1.25}, author = {Vigasini Subbiah and Pannaga Nagaraja and Priya Narayan and Holenarasipur GunduRao Nagendra} } @article {958, title = {Review on Chemical Constituents and Biological Activities of Genus Anthemis}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {1155-1166}, type = {Review Article}, chapter = {1155}, abstract = {

Genus Anthemis of Family Asteraceae contains mainly flavonoids, sesquiterpene lactones belonging to germacranolides, eudesmanolides, guaianolides, sterols and essential oils. The Plants of genus Anthemis have been known to have anti-inflammatory, hepatoprotective and antioxidant activities due to their rich contents of important physiological and biological compounds. They are referred to as nature{\textquoteright}s biological response modifier{\textquoteright}s and are involved in energy transfer, photosensitization and morphogenesis. Several clinical studies have shown that people who take diets rich in flavonoids and sesquiterpenes have reduced risk of developing cancer and cardiovascular diseases. This article covers most of constituents of plants of genus Anthemis reported from 2002 up to 2018. Furthermore, the biological activities of plants of genus Anthemis will be presented.

}, keywords = {Anthemis, Anti-inflammatory, Anti-oxidant, Flavonoids, Sesquiterpenes}, doi = {10.5530/pj.2019.11.180}, author = {Rima Boukhary and Maha Aboul-Ela and Abdalla El-Lakany} } @article {581, title = {Anti-Diabetic, Anti-Oxidant and Anti-Adipogenic Potential of Quercetin Rich Ethyl Acetate Fraction of Prunus persica}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {March 2018}, pages = {463-469}, type = {Original Article}, chapter = {463}, abstract = {

Background: Diabetes mellitus is enfeebling threatening diseases with continuously increasing rates of incidence and mortality and it may rise tremendously by 2025. Objective: Quercetin rich ethyl acetate fraction (PP-EtOA) of leaves of Prunus persica was evaluated for antidiabetic, anti-oxidant and anti-adipogenic activities. Material and Methods: Streptozotocin (STZ)-induced diabetic rat model, oral glucose tolerance test (OGTT) and normalglycemic rat models were investigated at the doseof 100 and 200 mg/kg,p.o. of PP-EtOA. Results: At 200 mg/kg, significant anti-hyperglycaemic activity(p\<0.05) was observed in all the rat models. In STZ induced diabetic rat model, improvement in body weight and lipid profile was also observed.DPPH (2,2\’-diphenyl-1-picrylhydrazyl) free radical scavenging method showed dose dependent scavenging. Preadipocyte differentiation assay (3T3-L1) showed significant inhibition of differentiation. HPLC fingerprinting analysis of fraction was also performed. Conclusion: PP-EtOA possesses potent free radical scavenging property. Its antihyperglycemic and antiadipogenic activities may be due to quercetin (flavonoid) and may prove to be effective in the treatment of diabetes mellitus and diabetes driven dyslipidemic conditions.

}, keywords = {Anti-adipogenic, Anti-diabetic, Anti-oxidant, Prunus persica, Quercetin}, doi = {10.5530/pj.2018.3.76}, url = {http://fulltxt.org/article/509}, author = {Gaurav Sharma and Sunil Kumar and Megha Sharma and Navneet Upadhyay and Sunil Kumar and Zabeer Ahmed and Neeraj Mahindroo} } @article {468, title = {Chemical Constituents from Salvia fruticosa libanotica}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {45-48}, type = {Original Article}, chapter = {45}, abstract = {

Objective: Plants of genus Salvia are used in traditional folk medicine for their antidiabetic, anti-oxidant effects and for gastric disorders. The oil has an antiseptic property and it is used as a fragrance in soaps and perfumes. An infusion of the leaves is widely used as a mouthwash or gargle and for the treatment of inflammation of the mouth and throat. It is used as carminative, antiinflammatory, astringent, cytotoxic and antispasmodic. Materials and Methods: Air-dried powdered aerial parts and roots of Salvia fruticosa libanotica were extracted separately with ethanol and acetone then their residues were separately extracted with different solvents on silica gel columns. Results: From Salvia fruticosa libanotica, eight phenolic compounds were isolated from methylene chloride, ethyl acetate and butanol extracts of the chosen plant. The chemical structures of the isolated compounds were determined by NMR, MS, IR and UV spectroscopic methods. Conclusion: Among these compounds three Flavonoids named apigenin, luteolin and rutin were identified in addition to three phenolic acids which are ferulic acid, gallic acid and rosemarinic acid from aerial parts. Moreover, carnosol and dehydro-abietic acid were also isolated from Salvia fruticosa\ libanotica \ root extract. All the isolated compounds were obtained for the first time from Salvia fruticosa libanotica .

}, keywords = {Anti-oxidant, Antidiabetic, Dehydroabietic acid, Rutin; Carnosol, Salvia fruticosa libanotica}, doi = {10.5530/pj.2018.1.9}, url = {http://fulltxt.org/article/364}, author = {Rima Boukhary and Maha Aboul-Ela and Othman Al-Hanbali and Abdalla El-Lakany} } @article {380, title = {Active Constituents of Pomegranates (Punica granatum) as Potential Candidates in the Management of Health through Modulation of Biological Activities}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {July 2017}, pages = {689-695}, type = {Original Article}, chapter = {689}, abstract = {

Pomegranates fruits have innumerable health benefits and its implication in diseases cure have been widely recognized since ancient time. Moreover, pomegranate fruits, seeds and peels are intensively used in traditional medicine as a natural therapy. It contains numerous valuable ingredients such as flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The principal constituents including punicalagins and ellagitannin are responsible for immeasurable health benefits due to its strong antioxidant activity. Additionally, constituents of pomegranate show health promoting effect through the modulation of physiological and biochemical pathways. Recent evidences suggested that pomegranates fruits, peels and seeds illustrate therapeutics implications in health management via inhibition of free radical effect and modulation of enzymes activity linked with diseases development and progression. In this review, we summarize the therapeutic role of pomegranate fruits, seeds and peels in the health managements based on in vitro and in vivo studies.

}, keywords = {Anti-inflammatory Effect, Anti-oxidant, Heptoprotective Effect, Neuroprotective Effect and Anti-microbial Effects, Pomegranates}, doi = {10.5530/pj.2017.5.109}, url = {/files/pj-9-5/10.5530pj.2017.5.109/index.html}, author = {Arshad Husain Rahmani and Mohamed Ali Alsahli and Saleh Abdulrahman Almatroodi} } @article {361, title = {Chemical Profile and Biological Activities of Essential oil of Aerial parts of Artemisia monosperma Del. Growing in Libya}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {578-586}, type = {Original Article}, chapter = {578}, abstract = {

Background: From the bioactivity stand point Artemisia monosperma Del. is reputed to have antispasmodic and anthelmintic properties. Various types of secondary metabolites were reported in A. monosperma plants from different localities. Objective: The current study was planned aiming to investigate the influence of stage of development on the composition, antimicrobial, antiinflammatory and antioxidant activities of the essential oil derived from the aerial parts of the Libyan plants. Material and Methods: A. monosperma volatiles were hydro-distilled from aerial parts of Libyan plants, collected at different stages of growth: before flowering (A1), and at beginning (A2) and by the end (A3) of flowering stage. Yields ranged from 0.16-0.26 ml/100g fresh material (A3, highest). GC/FID and GC/MS analyses were performed. Results: Among 16-20 identified components (97.63-99.00\% of total composition), 11 were common in all samples. A1 and A2 showed close amounts of hydrocarbons (63.56 and 66.55\%), but lesser than A3 (88.36\%); monoterpenoids were mainly represented by sabinene (13.15-22.85\%), \β-pinene (9.00-24.03\%) and \β-cis-ocimene (3.73-12.92\%); while sesquiterpenoids appeared absent. Among oxygenated components (11.29, 31.08 and 35.44 \% in A3, A2 and A1), bornyl acetate was the major monoterpenoid (8.00-31.00\%, highest in A1); and the sesquiterpenoid, \β-eudesmol (8.01\%) was detected in A2 only. Moreover, A2 demonstrated significant antifungal effect against Aspergillus fumigatus and Geotricum candidum (MIC 0.98 and 0.24 \μg/ml). Conclusion: A3 exerted the highest anti-inflammatory activity as compared to the other volatiles. A1 restored the reduced blood GHS level in diabetic animals almost as efficiently as Vitamin E. The antioxidant activity of the volatiles is decreased during the flowering stage, being the highest before flowering (A1); this could be associated to the decreasing bornyl acetate content of the samples.

}, keywords = {Anti-oxidant, Antiinflammatory, Antimicrobial, Artemisia monosperma, Essential oil composition, GC-MS, Libya.}, doi = {10.5530/pj.2017.4.92}, url = {/files/PJ-9-4/10.5530pj.2017.4.92}, author = {Soheir Mohamed El Zalabani and Soad Hanna Tadros and Abeer Mohamed El Sayed and Areej Almaktouf Daboub and Amany Amen Sleem} } @article {150, title = {Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {Jan/2016}, pages = {291-299}, type = {Original Article}, chapter = {291}, abstract = {

Background: Giardiasis is a debilitating disease caused by gastrointestinal parasites of the genus Giardia. Tasmannia lanceolata (Tasmanian pepper berry) has a high anti-oxidant capacity and has documented therapeutic properties for a variety of pathogenic diseases. Materials and methods: Solvent extracts of T. lanceolata berry and leaf were investigated for the ability to block G. duodenalis growth. The IC50 values of the extracts which displayed inhibitory activity were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Active extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. Results: Methanolic, aqueous and ethyl acetate T. lanceolata berry and leaf extracts displayed potent G. duodenalis growth inhibitory activity. The methanolic extracts were the most potent growth inhibitors with IC50 values of approximately 180 \µg/ml and 420 \µg/ml for the berry and leaf methanolic extracts respectively. The aqueous, ethyl acetate, chloroform and hexane extracts also inhibited G. duodenalis growth, albeit with lower potency. HPLC-QTOF mass spectroscopy analysis of the extracts identified 45 compounds which were present in all T. lanceolata berry extracts. Forty of these were putatively identified by screening against 3 compound databases. All T. lanceolata berry and leafextracts were nontoxic in the Artemia fransiscana bioassay. Conclusion: The low toxicity of the T. lanceolata extracts and their potent G. duodenalis growth inhibitory bioactivity indicates their potential as medicinal agents in the treatment and prevention of this disease.

}, keywords = {Alternative therapies, Anti-Giardial activity, Anti-oxidant, Complementary, Gastrointestinal parasite, Giardisis, Tasmanian pepper.}, doi = {10.5530/pj.2016.3.19}, author = {Paran Rayan and Ben Matthews and Pauline Mc Donnell and Ian Edwin Cock} } @article {166, title = {Phytopharmacological overview of Terminalia chebula Retz}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {307-309}, type = {Review Article}, chapter = {307}, abstract = {

Phytotherapy is the traditional method used to cure many diseases. Various medicinal plants found in many parts of India are well known for their various medicinal values. The Terminalia chebula Retz. a native plant of Asia is found to have various properties like anti-oxidant and free radical scavenging activity, anti-carcinogenic activity, ant-imutagenic activity, anti-bacterial activity, anti-fungal activity, anti-viral activity, anti-diabetic, renoprotective activity, cardio-protective activity, anti-inflammatory and anti-arthritic activity. These properties of T. chebula discussed in this review are mainly due to the presence of various types of phytoconstituents.

}, keywords = {Anti-arthritic, Anti-carcinogenic, Anti-fungal, Anti-inflammatory., Anti-oxidant, Free radical, Phytoconstituents, Renoprotective, Terminalia chebula}, doi = {10.5530/pj.2016.4.1}, author = {Agaath Hedina and Punniya Kotti and Juveriyah Kausar and Sivasamy and Vijaya Anand} } @article {175, title = {Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {310-313}, type = {Review Article}, chapter = {310}, abstract = {

The use of plant extract to cure diseases has been the traditional way used in many parts of the world. The synthetic drugs used now are more prone to cause side effects than curing the disease. Hence, the use of plant extract has now emerged due to their effective action against the disease without causing any side effects. The plants belonging to the family called Euphorbia are widely used in medicine for its wide medicinal properties. The plant Euphorbia hirta has properties like anti-bacterial, anti-diarrheal, anti-allergic, diuretic, anti-oxidant, anti-tumor, anti-diabetic, anxiolytic and sedative activity. This review contains the detailed information about all the properties of E. hirta.

}, keywords = {Anti-apoptotic., Anti-bacterial, Anti-oxidant, Diuretic, Euphorbia hirta, Sedative}, doi = {10.5530/pj.2016.4.2}, author = {Juveriyah Kausar and Durai Muthumani and Agaath Hedina and Sivasamy and Vijaya Anand} } @article {1482, title = {Anti-diabetic, Hypolipidemic and Anti-oxidant Activities of Hydroethanolic Root Extract of Rhus Mysurensis Heyne in Streptozotocin Induced Diabetes in Wistar Male Rats}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {62-71}, type = {Original Article}, abstract = {

Objectives: The present study was designed to investigate the potential role of hydroethanolic root extracts\  were Rhus mysurensis (HERM) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetes in Wistar rats. Methods: In this study, the anti-diabetic, hypolipidemic and anti-oxidant activities of hydroethanolic root extract of Rhus mysurensis was evaluated by using STZ induced diabetic rats at a dose of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. daily for 21 days. Blood glucose levels and body weight were monitored at specific time intervals, and different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein were also assessed in the experimental animals. Results: Oral administration of hydroethanolic root extracts of Rhus mysurensis (HERM) 400 and 800 mg/kg for 21 days significantly decreased the blood glucose level and considerably increased the body weight of diabetic induced rats. Daily oral treatment with HERM for 3 weeks resulted in reduced serum cholesterol, and triglycerides and improved HDL-cholesterol levels when compared to the diabetic control group. HERM significantly decreased thiobarbituric acid reactive substances (TBARS) and significantly increased superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 21 days of treatment. Conclusion: Hydroethanolic root extract of Rhus mysurensis showed significant anti-diabetic, hypolipidemic and anti-oxidant activities, which provide the scientific proof for its traditional claims. The results also put forward that the HERM is promising for development of standardized phytomedicine for the treatment of diabetes mellitus.

Key words: Anti-diabetic, anti-oxidant, hypolipidemic, Rhus mysurensis.

}, keywords = {Anti-diabetic, Anti-oxidant, Hypolipidemic, Rhus mysurensis.}, author = {Sanwar Mal Lamba, and Kunjbihari Sulakhiya, and Parveen Kumar, and Mangala Lahkar, and Chandana C. Barua, and Babul Bezbaruah} }