@article {2535, title = {A Prospective, Multi-centre, Open label, Single arm Study to Evaluate the Efficacy and Safety of Amlapitta Mishran Suspension in Participants with Amlapitta (Symptomatic Gastritis)}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {September 2025}, pages = {545-551}, type = {Original Article}, chapter = {545}, abstract = {

Introduction: The multi-center clinical study was conducted to revalidate the efficacy and safety of Amlapitta Mishran Suspension in Amlapitta (symptomatic gastritis) in a larger sample size in improving Amlapitta Symptom Rating Scale Score, PPDS score, EPS score, and safety. Methods: The study was a multi-centric, open-labeled, single-arm, prospective clinical trial in participants with Amlapitta (symptomatic gastritis). Participants with the presence of Amlapitta (symptomatic gastritis), as diagnosed by the Amlapitta Symptom Rating Scale Score >= 5 were included in the study. Participants were advised to take Amlapitta Mishran Suspension in a dose of 15 ml twice daily for 14 days. The study involved three visits. The investigator recorded the Amlapitta Symptom Rating Scale (ASRS) Score, Post Prandial Distress Syndrome (PPDS) Score, and Epigastric Pain Syndrome (EPS) Score at screening visit (Visit 1), baseline visit (Visit 2) and final visit (Visit 3). The p\<0.05 was considered statistically significant measured by paired t-test or Wilcoxon Signed Rank test. Results: In the multi-center study 204 participants completed the study. At final visit, a statistically significant (p\<0.001) reduction was reported in mean Total ASRS score, PPDS score, and EPS score as compared to the baseline scores. The individual ASRS, PPDS, and EPS variables also exhibited significant reduction (p\<0.001) at the final visit. None of the participants reported any adverse events during the study. Conclusion: Amlapitta Mishran Suspension treatment for 14 days effectively and safely reduced the clinical symptoms of Amlapitta (symptomatic gastritis) assessed by Amlapitta Symptom Rating Scale, Postprandial Distress Syndrome and Epigastric Pain Syndrome scores.

}, keywords = {Ayurveda, Gastritis, Symptom scores}, doi = {10.5530/pj.2025.17.68}, author = {Paresh G. Koli and Yashashri Shetty and Reetu Sharma and Bal Krishan Sevatkar and Anaya A. Pathrikar and Hemant S. Paradkar and Mukesh B Chawda and Sangam S. Narvekar and Megha L. Nalawade and Pawankumar R. Godatwar} } @article {2044, title = {Anti-Gastritis Activity of Cloves (Eugenia caryophyllata Thunberg) and Lime (Citrus aurantifolia) Leaf Extracts Combination in Absolute Alcohol Induced-Gastric Injury Mice}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {June 2023}, pages = {378-384}, type = {Research Article}, chapter = {378}, abstract = {

Background: Clove (Eugenia caryophyllata Thunberg) and lime (Citrus aurantifolia) are medicinal plants traditionally used to treat various diseases such as gastritis. Some studies reported that cloves leaf and lime leaf extract showed a gastroprotective effect by decreasing the gastric acid secretion and increasing the gastric mucus. Aim: This study aims to investigate the anti-gastritis activity of the combination of ethanolic extract of cloves leaf and lime leaf extract in alcohol absolute-induced mice. Methods: Mice were treated with the combination extract 0.7 g/kg BW, 1.4 g/kg BW, and 2.8 g/kg BW. Famotidine was used as a positive control, and Na CMC suspension was used as a negative control. After 45 minutes of oral administration, 0.14 ml/20g BW alcohol absolute was given to all mice. All groups were sacrificed one hour later. The evaluation showed that extract combination in all doses significantly decreased ulcer index (UI) compared to a negative control group (p\<0.005) in macroscopic evaluation. Results: In histopathologic evaluation, all doses significantly decreased mucosal edema and epithelial cell loss (p\<0.005), but in gastric bleeding evaluation, only 0.7 and 1.4 g/kg BW doses showed a significant decrease. Conclusion: This study showed that a combination of clove and lime leaf extracts has anti-gastritis activity and could be a possible therapeutic of anti-gastritis. The most effective dose is 1.4 g/kg BW in mice which showed the lowest ulcer index and gastric mucosal edema, bleeding and epithelial cells loss reduction on histopathological observation.

}, keywords = {Citrus aurantifolia, Clove, Eugenia caryophyllata, Gastritis, Lime, Ulcer}, doi = {10.5530/pj.2023.15.88}, author = {Herra Studiawan and Sukardiman and Indana Lazulfa and Rosita Handayani} }