@article {2233, title = {Test of Antihyperuricemia Activity of Methanol Extract of Plantain Peel (Musa Paradisiaca Var. Sapientum) Against Caffeine- Induced Mice (Mus Musculus)}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {February 2024}, pages = {226-230}, type = {Research Article}, chapter = {226}, abstract = {

Background: Hyperuricemia occurs when serum uric acid levels rise above the normal range, typically exceeding 7.0 mg/dl for adults and 6.0 mg/dl for women. This condition can lead to various health issues, including gout, kidney stones, and renal failure. Objective: This study aims to verify the effectiveness of the methanol extract from plantain peel (Musa paradisiaca var. sapientum) in reducing uric acid levels in mice (Mus musculus) and to establish the optimal dosage for maximum efficacy. Materials and Methods: This analytical experimental research utilized a paired sample T-test Pretest-Posttest design. The mice were divided into five groups: a Negative Control of Na.CMC 0.5\%, a Positive Control of allopurinol at 100 mg/kg body weight, and groups receiving plantain peel methanol extract at 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight. Uric acid levels were measured initially, post-caffeine induction on day 7, and post-extract induction on day 14. Results: The study found that plantain peel methanol extract exhibited an anti-hyperuricemic effect in male mice. Among the dosages tested, 400 mg/kg body weight of the plantain peel methanol extract was the most effective in reducing uric acid levels, followed by the 200 mg/kg and 100 mg/kg doses. Conclusion: Plantain peel methanol extract is effective in reducing uric acid levels in male mice, with 400 mg/kg being the most efficacious dosage. This suggests potential for further exploration of plantain peels as a treatment for hyperuricemia.

}, keywords = {Anti-hyperuricemic effect, Hyperuricemia, Methanol extract, Mus musculus, Optimal dosage, Plantain peel, Uric acid levels}, doi = {10.5530/pj.2024.16.32}, author = {Ratna Umi Nurlila and Jumarddin La Fua and Toto Surianto S and Titi Purnama and Muh Ikhsan Idrus and Armayani and Anwar Mallongi} } @article {2013, title = {Molecular Docking and ADME Studies of Centella Asiatica as Anti Hyperuricemia}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {384-389}, type = {Research Article}, chapter = {384}, abstract = {

Centella asiatica is a traditional natural medicine used in a number of Southeast Asian nations. (also known as Centella asiatica L., Urb., or Gotu Kola). The aim of this study is to determine the antihyperuricemia properties of Centella asiatica extract and the possibility that they will interact with the XDH enzyme. The XDH enzyme is one of three enzymes that can influence the onset of hyperuricemia with the other two are SLC22A12 and ABCG2. In this research, we employ a computational method in collaboration with a number of applications and databases. ADME analysis was carried on for some Centella asiatica constituents to determine their similarities to the drug and bioavailability components. The analysis continued on with molecular docking between the chemical compounds and several enzymes related to hyperuricemia. According to the findings, Centella asiatica contains active constituents that can be used as an alternative therapy for hyperuricemia.

}, keywords = {Centella asiatica, Hyperuricemia, Molecular Docking.}, doi = {10.5530/pj.2023.15.59}, author = {Ahmad Shobrun Jamil and Prayogi Galie Saputro} }